{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T14:07:07Z","timestamp":1792850827387,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,8,2]],"date-time":"2020-08-02T00:00:00Z","timestamp":1596326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Although dementia with Lewy bodies (DLB) is characterized by a variety of initial symptoms, there are almost no reports of the initial symptoms of DLB assessed in a large number of cases. We retrospectively evaluated the initial symptoms of 234 participants with DLB and DLB\u2010related symptoms at diagnosis and characterized any gender differences in the symptom profiles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study consisted of 234 participants with probable DLB who met the diagnostic criteria outlined in the Fourth Consensus Report of the DLB Consortium (2017). DLB was confirmed based on several characteristic biomarkers for dopamine transporter imaging with <jats:sup>123<\/jats:sup>I\u2010N\u2010omega\u2010fluoropropyl\u20102\u2010beta\u2010carbomethoxy\u20103\u2010beta (4\u2010iodophenyl) nortropane single\u2010photon emission computed tomography, <jats:sup>123<\/jats:sup>I\u2010metaiodobenzylguanidine myocardial scintigraphy, and brain perfusion measured with single photon emission computed tomography. In addition, core and supportive clinical features were considered in the diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Initial symptoms included cognitive impairment (41.9%) and psychiatric symptoms (i.e. visual and auditory hallucinations, delusions, and depression) (42.3%). Almost half of the women initially presented with psychiatric symptoms, with significantly more women than men presenting with auditory hallucinations. In contrast, men had a significantly higher rate of rapid eye movement sleep behaviour disorder (RBD) than women did. At diagnosis, DLB\u2010related symptoms differed between men and women, with male patients exhibiting significantly more RBD, parkinsonism, hyposmia, and syncope than female patients. Moreover women presented significantly more often with auditory hallucinations than did men.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results indicate that there are gender differences in the initial symptoms of DLB, as well as in the presentation of subsequent symptoms observed at diagnosis. There was a higher incidence of RBD in men, whereas women had a higher incidence of psychotic symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/psyg.12586","type":"journal-article","created":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T00:43:54Z","timestamp":1596415434000},"page":"737-745","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Characteristics of initial symptoms and symptoms at diagnosis in probable dementia with Lewy body disease: incidence of symptoms and gender differences"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2781-3303","authenticated-orcid":false,"given":"Kumiko","family":"Utsumi","sequence":"first","affiliation":[{"name":"Department of Psychiatry Sunagawa City Medical Center  Sunagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4091-2800","authenticated-orcid":false,"given":"Ryo","family":"Fukatsu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Nishi Kumagaya Hospital  Kumagaya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1238-1034","authenticated-orcid":false,"given":"Ritsuko","family":"Yamada","sequence":"additional","affiliation":[{"name":"School of Nursing and Social Services Health Sciences University of Hokkaido  Tobetsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7003-559X","authenticated-orcid":false,"given":"Yuji","family":"Takamaru","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Otaru General Hospital  Otaru Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1721-856X","authenticated-orcid":false,"given":"Yuko","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Nishi Kumagaya Hospital  Kumagaya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7783-7904","authenticated-orcid":false,"given":"Shuichi","family":"Yasumura","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Sapporo Sato Hospital  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00685366"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00690978"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00342237"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(03)00619-7"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.12466"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0891988716656083"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0072-9752(07)01229-8"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2010.03.007"},{"key":"e_1_2_5_10_1","first-page":"173","article-title":"The incidences of initial symptoms and relevant symptoms of dementia with Lewy bodies, and sex difference, and the relation of prodromal stage: relationship of these symptoms and SPECT, MIBG, DaT","volume":"28","author":"Utsumi K","year":"2017","journal-title":"Rounen Seishin Igaku Zasshi"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004058"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-317398"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-018-3976-5"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0b013e328013eb8b"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4742"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000339363"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23557"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/psyg.12005"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000441443"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00314594"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acy034"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.5332"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/31.5.717"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05115.x"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31822c9148"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70476-8"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000340980.19702.6e"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001204"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(02)00065-9"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22282"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23602"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23792"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2011.97"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2015.06.013"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2012.10.015"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70471-9"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.5.1113"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2003.023812"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.17m11623"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/19.4.691"},{"key":"e_1_2_5_41_1","first-page":"217","volume-title":"Schizophrenia and aging: Shizophrenia, paranoia, and schizophreniform disorders in later life","author":"Roth M","year":"1987"}],"container-title":["Psychogeriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/psyg.12586","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/psyg.12586","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/psyg.12586","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T15:30:59Z","timestamp":1693841459000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/psyg.12586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,2]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1111\/psyg.12586"],"URL":"https:\/\/doi.org\/10.1111\/psyg.12586","archive":["Portico"],"relation":{},"ISSN":["1346-3500","1479-8301"],"issn-type":[{"value":"1346-3500","type":"print"},{"value":"1479-8301","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,2]]},"assertion":[{"value":"2019-04-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}