{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:57:40Z","timestamp":1747187860566,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T00:00:00Z","timestamp":1636502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Behavioural and psychological symptoms of dementia affect in a great way quality of life of both patients and their caregivers, which increases the risk of patient institutionalisation when such symptoms are poorly controlled. One of the drugs that are used for controlling behavioural and psychological symptoms of dementia (BPSD) is aripiprazole. This narrative review aims to solve three basic questions. Is aripiprazole useful for the management of these symptoms? Does aripiprazole play a substantial role regarding safety and efficacy, compared with the other pharmacological options available for the same purpose? Has aripiprazole gained importance in treatment regimens of these symptoms, in current clinical practice? We conclude that aripiprazole is effective to manage BPSD. Moreover, it has shown a good safety profile compared with other antipsychotics in advanced disease and frail patients. Thus, aripiprazole has gained importance in current management algorithms for dementia patients mainly due to its efficacy regarding rapid control of agitation and aggressiveness.<\/jats:p>","DOI":"10.1111\/psyg.12787","type":"journal-article","created":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T01:05:39Z","timestamp":1636592739000},"page":"137-144","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Role of aripiprazole in the management of behavioural and psychological symptoms of dementia: a narrative review"],"prefix":"10.1111","volume":"22","author":[{"given":"Baldomero","family":"\u00c1lvarez\u2010Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"Geriatrics Unit, Department of Internal Medicine, Regional University Hospital of Malaga, Instituto de Investigaci\u00f3n Biom\u00e9dica de Malaga (IBIMA) University of Malaga  Malaga Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0238-0890","authenticated-orcid":false,"given":"M. Rosa","family":"Bernal\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Geriatrics Unit, Department of Internal Medicine, Regional University Hospital of Malaga, Instituto de Investigaci\u00f3n Biom\u00e9dica de Malaga (IBIMA) University of Malaga  Malaga Spain"},{"name":"CIBER Fisiopatolog\u00eda de la Obesidad y la Nutrici\u00f3n, Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"G\u00f3mez\u2010Huelgas","sequence":"additional","affiliation":[{"name":"Geriatrics Unit, Department of Internal Medicine, Regional University Hospital of Malaga, Instituto de Investigaci\u00f3n Biom\u00e9dica de Malaga (IBIMA) University of Malaga  Malaga Spain"},{"name":"CIBER Fisiopatolog\u00eda de la Obesidad y la Nutrici\u00f3n, Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.7b00087"},{"key":"e_1_2_8_3_1","first-page":"113","article-title":"Aripiprazole (Otsuka Pharmaceutical Co)","volume":"3","author":"Ozdemir V","year":"2002","journal-title":"Curr Opin Investig Drugs"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.033175"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S3351"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S6411"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1166(200004)15:1 <S2::AID-GPS159>3.0.CO;2-3"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/55.1.S2"},{"key":"e_1_2_8_9_1","first-page":"539","article-title":"Advances in pharmacotherapy of psychotic disorders in the elderly","volume":"18","author":"Kirkwood CK","year":"2003","journal-title":"Consult Pharm"},{"key":"e_1_2_8_10_1","first-page":"5","article-title":"Expert consensus panel for using antipsychotic drugs in older patients. Using antipsychotic agents in older patients","volume":"65","author":"Alexopoulos GS","year":"2004","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.jcp.0000178415.22309.8f"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e3181557b47"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e318165db77"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2008.06.006"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1360"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-140579"},{"key":"e_1_2_8_17_1","doi-asserted-by":"crossref","unstructured":"TanL TanL WangHFet al.Efficacy and safety of atypical antipsychotic drug treatment for dementia: a systematic review and meta\u2010analysis.2015;7:20.https:\/\/doi.org\/10.1186\/s13195-015-0102-9Retraction in: Tan L Tan L Wang HF et al.Alzheimers Res Ther2016;8(1): 28.","DOI":"10.1186\/s13195-015-0102-9"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-308112"},{"key":"e_1_2_8_19_1","first-page":"453","article-title":"Antipsic\u00f3ticos at\u00edpicos: \u00bfh\u00e9roes o villanos? Una perspectiva cl\u00ednica","volume":"24","author":"Alvarez\u2010Fern\u00e1ndez B","year":"2007","journal-title":"An Med Interna"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1928"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.0828"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-019-09200-8"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2015.173501"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14412"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881117744996"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2020.113641"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h369"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610218000534"}],"container-title":["Psychogeriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/psyg.12787","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/psyg.12787","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/psyg.12787","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T10:11:33Z","timestamp":1693217493000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/psyg.12787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,10]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1111\/psyg.12787"],"URL":"https:\/\/doi.org\/10.1111\/psyg.12787","archive":["Portico"],"relation":{},"ISSN":["1346-3500","1479-8301"],"issn-type":[{"type":"print","value":"1346-3500"},{"type":"electronic","value":"1479-8301"}],"subject":[],"published":{"date-parts":[[2021,11,10]]},"assertion":[{"value":"2021-07-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}