{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T14:43:53Z","timestamp":1792853033798,"version":"4.5.0"},"reference-count":122,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T00:00:00Z","timestamp":1651276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:p>The brain ventricles are structures that have been related to cognition since antiquity. They are essential components in the development and maintenance of brain functions. The aging process runs with the enlargement of ventricles and is related to a less selective blood\u2010cerebrospinal fluid barrier and then a more toxic cerebrospinal fluid environment. The study of brain ventricles as a biological marker of aging is promissing because they are structures easily identified in neuroimaging studies, present good inter\u2010rater reliability, and measures of them can identify brain atrophy earlier than cortical structures. The ventricular system also plays roles in the development of dementia, since dysfunction in the clearance of beta\u2010amyloid protein is a key mechanism in sporadic Alzheimer's disease. The morphometric and volumetric studies of the brain ventricles can help to distinguish between healthy elderly and persons with mild cognitive impairment (MCI) and dementia. Brain ventricle data may contribute to the appropriate allocation of individuals in groups at higher risk for MCI\u2010dementia progression in clinical trials and to measuring therapeutic responses in these studies, as well as providing differential diagnosis, such as normal pressure hydrocephalus. Here, we reviewed the pathophysiology of healthy aging and cognitive decline, focusing on the role of the choroid plexus and brain ventricles in this process.<\/jats:p>","DOI":"10.1111\/psyg.12839","type":"journal-article","created":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T11:21:10Z","timestamp":1651317670000},"page":"544-552","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Brain ventricles, <scp>CSF<\/scp> and cognition: a narrative review"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9002-107X","authenticated-orcid":false,"given":"M\u00e1rio Luciano","family":"de M\u00e9lo Silva J\u00fanior","sequence":"first","affiliation":[{"name":"Medical School Universidade Federal de Pernambuco  Recife Brazil"},{"name":"Medical School Centro Universit\u00e1rio Maur\u00edcio de Nassau  Recife Brazil"},{"name":"Neurology Unit Hospital da Restaura\u00e7\u00e3o  Recife 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