{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:58:01Z","timestamp":1747187881948,"version":"3.40.5"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T00:00:00Z","timestamp":1685318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The noradrenergic systems in the brain maintain cognitive functions including attention\/concentration and establishment of long\u2010term memory. In addition, hypofunction of noradrenergic systems is supposed to be involved in the pathophysiology of Alzheimer's disease. In this study, we tried to examine the possible associations of concentrations of basal salivary 3\u2010methoxy\u20104\u2010hydroxyphenylglycol (sMHPG), a major metabolite of noradrenaline, and brain volume changes during 4\u2009years in elderly people living in a rural community.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The survey was conducted twice in Kurokawa\u2010cho, Imari, Saga Prefecture, Japan, among people aged 65\u2009years and older. We collected data from 226 residents. Measurements of sMHPG and brain MRIs were collected at Time 1 (2005\u20132007). Follow\u2010up brain MRIs were taken at Time 2 (2009\u20132011). A total of 70 participants (18 men, mean age 71.9\u2009\u00b1\u20094.8\u2009years; 52 women, mean age 72.0\u2009\u00b1\u20094.3\u2009years) completed this survey. Concentrations of sMHPG at baseline were divided into two groups using the mean value (12.83\u2009ng\/ml). We compared the brain volumes between groups with higher and lower sMHPG concentrations over time using voxel\u2010based morphometry implemented with statistical parametric mapping.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In participants with higher sMHPG concentrations at baseline, brain volumes including right precuneus were significantly larger 4\u2009years after baseline than those with lower sMHPG concentrations at baseline. No interaction between sMHPG concentration and MRI acquisition interval was found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that higher sMHPG concentrations in elderly people might be associated with maintenance of brain volume, especially in brain regions closely related to cognitive function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/psyg.12976","type":"journal-article","created":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T01:04:13Z","timestamp":1685408653000},"page":"675-681","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Salivary 3\u2010methoxy\u20104\u2010hydroxyphenylglycol and <scp>MRI<\/scp>\u2010based volume change of the precuneus in community\u2010dwelling elderly people"],"prefix":"10.1111","volume":"23","author":[{"given":"Junko","family":"Ohishi\u2010Fukuchi","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Faculty of 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