{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T05:13:06Z","timestamp":1792127586342,"version":"4.4.0"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,6,4]],"date-time":"2023-06-04T00:00:00Z","timestamp":1685836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Caring for patients with dementia with Lewy bodies (DLB) would be more stressful for their caregivers than those with Alzheimer's disease (AD). In this study, we compared levels of caregiver burden and the possible influential factors on the caregiver burden between DLB and AD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety\u2010three DLB patients and 500 AD patients were selected from the Kumamoto University Dementia Registry. Caregiver burden, neuropsychiatric symptoms, basic activities of daily living (BADL) and instrumental activities of daily living (IADL) were assessed by the Japanese version of the Zarit Caregiver Burden Interview (J\u2010ZBI), the Neuropsychiatric Inventory (NPI), the Physical Self\u2010Maintenance Scale (PSMS), and the Lawton IADL scale, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Despite the comparable Mini\u2010Mental State Examination score, the J\u2010ZBI score was significantly higher in the DLB group than the AD group (<jats:italic>P<\/jats:italic>\u2009=\u20090.012). A stepwise multiple regression analysis revealed that IADL score (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.23, <jats:italic>P<\/jats:italic>\u2009=\u20090.049), PSMS score (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.31, <jats:italic>P<\/jats:italic>\u2009=\u20090.010), disinhibition (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.22, <jats:italic>P<\/jats:italic>\u2009=\u20090.008), and anxiety (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.19, <jats:italic>P<\/jats:italic>\u2009=\u20090.027) were significantly associated with J\u2010ZBI score in DLB. In AD, caregiver's relationship with patient (child) (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.104, <jats:italic>P<\/jats:italic>\u2009=\u20090.005), caregiver's gender (female) (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.106, <jats:italic>P<\/jats:italic>\u2009=\u20090.004), IADL score (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.237, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), irritability (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.183, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), apathy (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.132, <jats:italic>P<\/jats:italic>\u2009=\u20090.001), agitation (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.118, <jats:italic>P<\/jats:italic>\u2009=\u20090.007), and aberrant motor behaviour (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.107, <jats:italic>P<\/jats:italic>\u2009=\u20090.010) were associated with caregiver burden.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Caring for DLB patients caused a higher degree of caregiver burden than AD patients in the same level of cognitive decline. The factors responsible for the caregiver's burden were different between DLB and AD. The caregiver burden for DLB patients was associated with the disability of basic ADL, IADL impairment, anxiety and disinhibition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/psyg.12978","type":"journal-article","created":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:59:25Z","timestamp":1686013165000},"page":"682-689","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Comparison of caregiver burden between dementia with Lewy bodies and Alzheimer's disease"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0925-7964","authenticated-orcid":false,"given":"Seiji","family":"Yuuki","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry Kumamoto University Hospital  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamoru","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Kindai University Faculty of Medicine  Osaka\u2010Sayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asuka","family":"Koyama","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Faculty of Life Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masateru","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Department of Psychology, Faculty of Human Sciences Konan Woman's University  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohisa","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Arao Kokoronosato Hospital  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuji","family":"Fukuhara","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Kagoshima University Graduate School of Medical and Dental Sciences  Kagoshima 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