{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:58:04Z","timestamp":1747187884607,"version":"3.40.5"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:00:00Z","timestamp":1688083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The relationship between vitamin D and cognitive status remains controversial. We aimed to evaluate the effect of vitamin D replacement on cognitive functions in healthy and cognitively intact vitamin D deficient older females.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was designed as a prospective interventional study. A total of 30 female adults aged \u226560 with a serum 25 (OH) vitamin D level of &lt;10 ng\/ml were included. Participants were administered 50\u2009000 IU vitamin D3 weekly for 8\u2009weeks followed by a maintenance therapy of 1000 U\/day. Detailed neuropsychological assessment was performed prior to vitamin D replacement and repeated at 6\u2009months by the same psychologist.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean age was 63\u2009\u00b1\u20096.7\u2009years and baseline vitamin D level was 7.8\u2009\u00b1\u20092.0 (range: 3.5\u201310.3) ng\/ml. At 6\u2009months, vitamin D level was 32.5\u2009\u00b1\u20093.4 (32.2\u201355) ng\/ml. The Judgement of Line Orientation Test (<jats:italic>P<\/jats:italic>\u2009=\u20090.04), inaccurate word memorizing of the Verbal Memory Processes Test (<jats:italic>P<\/jats:italic>\u2009=\u20090.02), perseveration scores of the Verbal Memory Processes Test (<jats:italic>P<\/jats:italic>\u2009=\u20090.005), topographical accuracy of the Warrington Recognition Memory Test (<jats:italic>P<\/jats:italic>\u2009=\u20090.002), and the spontaneous self\u2010correction of an error in the Boston Naming Test (<jats:italic>P<\/jats:italic>\u2009=\u20090.003) scores increased significantly, while the delayed recall score in the Verbal Memory Processes Test (<jats:italic>P<\/jats:italic>\u2009=\u20090.03), incorrect naming of words in the Boston Naming Test (<jats:italic>P<\/jats:italic>\u2009=\u20090.04), interference time of the Stroop Test (<jats:italic>P<\/jats:italic>\u2009=\u20090.05), and spontaneous corrections of the Stroop Test (<jats:italic>P<\/jats:italic>\u2009=\u20090.02) scores decreased significantly from baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Vitamin D replacement has a positive effect on cognitive domains related to visuospatial, executive, and memory processing functions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/psyg.12997","type":"journal-article","created":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:48:21Z","timestamp":1688172501000},"page":"781-788","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The effect of vitamin D on neurocognitive functions in older vitamin D deficient adults: a pilot longitudinal interventional study"],"prefix":"10.1111","volume":"23","author":[{"given":"Banu Ozulu","family":"Turkmen","sequence":"first","affiliation":[{"name":"Istanbul Medical School, Department of Internal Medicine, Division of Geriatrics Istanbul University  Istanbul 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