{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T03:47:55Z","timestamp":1783396075059,"version":"3.54.6"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:00:00Z","timestamp":1694044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The containment measures linked to the COVID\u201019 pandemic negatively affected the phyco\u2010physical well\u2010being of the population, especially older adults with neurocognitive disorders (NCDs). This study aims to evaluate whether the frailty of NCD patients was associated with different changes in multiple health domains, in particular in relation to loneliness and social isolation, pre\u2010 and post\u2010lockdown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Patients were recruited from 10 Italian Centers for Cognitive Disorders and Dementia. Data were collected in the pre\u2010pandemic period (T0), during the pandemic lockdown (T1), and 6\u20139\u2009months post\u2010lockdown (T2). The UCLA Loneliness Scale\u20103, Activities of Daily Living (ADL), Instrumental ADL (IADL), Mini\u2010Mental State Examination, and Neuropsychiatric Inventory (NPI) were administered. Caregivers' burden was also tested. Patients were categorized as non\u2010frail, pre\u2010frail, and frail according to the Fatigue, Resistance, Ambulation, Illness, and Loss of Weight scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The sample included 165 subjects (61.9% women, mean age 79.5\u2009\u00b1\u20094.9\u2009years). In the whole sample, the ADL, IADL, and NPI scores significantly declined between T0 and T2. There were no significative variations in functional and cognitive domains between the frail groups. During lockdown we recorded higher Depression Anxiety Stress Scales and Perceived Stress Scale scores in frail people. In multivariable logistic regression, frailty was associated with an increase in social isolation, and a loss of IADL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We observed a global deterioration in functional and neuro\u2010psychiatric domains irrespective of the degree of frailty. Frailty was associated with the worsening of social isolation during lockdown. Frail patients and their caregivers seemed to experience more anxiety and stress disorders during SARS\u2010CoV\u20102 pandemic.<\/jats:p><\/jats:sec>","DOI":"10.1111\/psyg.13021","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T05:49:25Z","timestamp":1694152165000},"page":"1007-1018","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Frailty, psychological <scp>well\u2010being,<\/scp> and social isolation in older adults with cognitive impairment during the <scp>SARS\u2010CoV<\/scp>\u20102 pandemic: data from the GeroCovid initiative"],"prefix":"10.1111","volume":"23","author":[{"given":"Camilla","family":"Terziotti","sequence":"first","affiliation":[{"name":"Department of Medicine (DIMED), Geriatrics Division University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5064-1672","authenticated-orcid":false,"given":"Chiara","family":"Ceolin","sequence":"additional","affiliation":[{"name":"Department of Medicine (DIMED), Geriatrics Division University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5899-8000","authenticated-orcid":false,"given":"Maria","family":"Devita","sequence":"additional","affiliation":[{"name":"Department of Medicine (DIMED), Geriatrics Division University of Padova  Padova Italy"},{"name":"Department of General Psychology University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Raffaelli","sequence":"additional","affiliation":[{"name":"Department of Medicine (DIMED), Geriatrics Division University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Antenucci","sequence":"additional","affiliation":[{"name":"Psychogeriatric Outpatient Clinic  Ortona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Bazzano","sequence":"additional","affiliation":[{"name":"Geriatrics Unit Azienda ULSS 16  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Capasso","sequence":"additional","affiliation":[{"name":"Territorial Care Department ASL NA2 Nord  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Castellino","sequence":"additional","affiliation":[{"name":"\u201cB.V. 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