{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T03:53:50Z","timestamp":1781495630540,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients displaying clinical features of behavioural variant of frontotemporal dementia (bvFTD) but lacking both neuroimaging abnormalities and clinical progression are considered to represent the phenocopy syndrome of bvFTD (phFTD). Extensive clinical overlap between early phase bvFTD and phFTD hampers diagnostic distinction. We aimed to assess the diagnostic value of clinician\u2010rated, self\u2010reported and caregiver\u2010reported symptoms for clinical distinction between phFTD and bvFTD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      There were 33 phFTD and 95 probable bvFTD patients included in the study (total\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009128). Clinician\u2010rated, self\u2010reported tests and caregiver\u2010reported symptoms were compared between phFTD and bvFTD on social cognition, behaviour, mood and activities of daily living (ADL). Scores were compared between groups, followed by multiple logistic regression analysis, adjusted for age and sex. Receiver operating characteristic curves were plotted to assess diagnostic value.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Using clinician\u2010rated and self\u2010reported tests, phFTD patients performed better on facial emotion recognition and reported more depressive symptoms. Caregiver\u2010reported behavioural symptoms indicated higher behavioural and ADL impairment in phFTD compared to bvFTD. Facial emotion recognition provided highest diagnostic accuracy for distinction of phFTD from bvFTD (area under the curve (AUC) 0.813 95% CI 0.735\u20130.892,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001, sensitivity 81%, specificity 74%) followed by depressive symptoms (AUC 0.769 95% 0.674\u20130.864,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001 sensitivity 81%, specificity of 63%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Social cognition tests are most suitable for distinction of phFTD from bvFTD. Caregiver\u2010reported questionnaires and phFTD diagnosis seemed inversely correlated, showing more symptoms in phFTD. Further research is needed on phFTD aetiology and in caregivers taking into account disease burden to assess what explains this discrepancy between clinician\u2010rated and caregiver\u2010based tools.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/psyg.13107","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T02:25:00Z","timestamp":1712111100000},"page":"741-751","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Social cognition differentiates phenocopy syndrome of behavioural variant frontotemporal dementia from behavioural variant frontotemporal dementia"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5293-0806","authenticated-orcid":false,"given":"Marie\u2010Paule E.","family":"van Engelen","sequence":"first","affiliation":[{"name":"Alzheimer Centre Amsterdam, Neurology Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc  Amsterdam The Netherlands"},{"name":"Amsterdam Neuroscience Neurodegeneration  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulette","family":"Louwers","sequence":"additional","affiliation":[{"name":"Alzheimer Centre Amsterdam, Neurology Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc  Amsterdam The Netherlands"},{"name":"Amsterdam Neuroscience Neurodegeneration  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9664-4075","authenticated-orcid":false,"given":"Jay L. 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M.","family":"de Boer","sequence":"additional","affiliation":[{"name":"Alzheimer Centre Amsterdam, Neurology Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc  Amsterdam The Netherlands"},{"name":"Amsterdam Neuroscience Neurodegeneration  Amsterdam The Netherlands"},{"name":"The University of Sydney School of Psychology  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemieke","family":"Dols","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University Medical Centre Utrecht  Utrecht The Netherlands"},{"name":"Department of Psychiatry, Amsterdam Neuroscience, Mood Anxiety Psychosis Sleep &amp; Stress Program Amsterdam UMC  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Scheltens","sequence":"additional","affiliation":[{"name":"Alzheimer Centre Amsterdam, Neurology Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc  Amsterdam The Netherlands"},{"name":"Amsterdam Neuroscience Neurodegeneration  Amsterdam The Netherlands"},{"name":"EQT Life Sciences Partners  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigfried N. T. M.","family":"Schouws","sequence":"additional","affiliation":[{"name":"Department of Old Age Psychiatry and Neuropsychiatry GGZ inGeest Specialised Mental Health Care, Location De Nieuwe Valerius  Amsterdam The Netherlands"},{"name":"Amsterdam UMC Location Vrije Universiteit Amsterdam, Psychiatry  Amsterdam The Netherlands"},{"name":"Amsterdam Public Health Research Institute, Mental Health  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolande A. L.","family":"Pijnenburg","sequence":"additional","affiliation":[{"name":"Alzheimer Centre Amsterdam, Neurology Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc  Amsterdam The Netherlands"},{"name":"Amsterdam Neuroscience Neurodegeneration  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Everard G. 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