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There is evidence of the beneficial effect of combined administration of \u03c9\u20103 PUFA and other dietary supplements such as vitamins and polyphenols in the prevention of AD, although much remains to be understood about their possible complementary or synergistic activity. Therefore, the objective of this work is to review the research focused on studying the effect and mechanisms of action of curcumin, \u03c9\u20103 PUFA, and the combination of these nutraceutical compounds, particularly on AD, and to integrate the possible ways in which these compounds can potentiate their effect. The most important pathophysiologies that manifest in AD will be addressed, in order to have a better understanding of the mechanisms of action through which these bioactive compounds exert a neuroprotective effect.<\/jats:p>","DOI":"10.1111\/psyg.13115","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T04:49:11Z","timestamp":1711428551000},"page":"701-718","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Curcumin and omega\u20103 polyunsaturated fatty acids as bioactive food components with synergistic effects on Alzheimer's disease"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5774-9106","authenticated-orcid":false,"given":"Luz del C.","family":"Velasco\u2010Rodr\u00edguez","sequence":"first","affiliation":[{"name":"UNIDA, Tecnol\u00f3gico Nacional de M\u00e9xico\/IT de Veracruz  Veracruz 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