{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T23:37:49Z","timestamp":1788824269349,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T00:00:00Z","timestamp":1716854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T00:00:00Z","timestamp":1716854400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    To assess the correlation between preoperative neutrophil\u2010to\u2010lymphocyte ratio (NLR) and risk of postoperative delirium (POD) in older patients undergoing noncardiac surgery. PubMed, Web of Science, Embase, and Scopus were systematically retrieved from inception until February 2023. Two authors independently conducted the selection of literature, data extraction and statistical analysis. In this meta\u2010analysis, Review Manager 5.4 was used for statistical analysis, and the mean difference (MD) and 95% confidence intervals (CIs) of preoperative NLR between the POD group and non\u2010POD group were calculated. We utilised the Newcastle\u2013Ottawa Scale (NOS) to evaluate the quality of literature. Further, our meta\u2010analysis used a random\u2010effects model, and publication bias was evaluated by conducting a funnel plot. The correlation between preoperative NLR and POD was the primary outcome, and the secondary outcome was the association of other prognostic factors with the risk of POD. This meta\u2010analysis included seven studies with 2424 patients, of whom 403 were diagnosed with POD with an incidence of 16.63%. Results indicated a positive correlation between preoperative NLR and the risk of POD (MD\u2009=\u20091.06, 95% CI: 0.64\u20131.49;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001). Further, our results found that neutrophil counts, advanced age, longer surgery time, diabetes, and elevated C\u2010reactive protein\u00a0were significantly associated with POD (MD\u2009=\u20090.98, 95% CI: 0.40\u20131.56;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.001; MD\u2009=\u20094.20, 95% CI: 2.90\u20135.51;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001; MD\u2009=\u20090.15, 95% CI: 0.05\u20130.25;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.01; OR\u2009=\u20091.42, 95% CI: 1.08\u20131.86;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.01; MD\u2009=\u20091.26, 95% CI: 0.36\u20132.16;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.01). Other factors including lymphocyte counts, hypertension and male gender were not significantly associated with POD (MD\u2009=\u2009\u22120.11, 95% CI: \u22120.27 to 0.05;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&gt;\u20090.05; OR\u2009=\u20091.20, 95% CI: 0.91\u20131.58,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&gt;\u20090.05; OR\u2009=\u20091.28, 95% CI: 1.00\u20131.63;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.05). Our meta\u2010analysis indicated a positive correlation between preoperative NLR and the risk of POD in older noncardiac surgery patients.\n                  <\/jats:p>","DOI":"10.1111\/psyg.13138","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T23:14:31Z","timestamp":1716938071000},"page":"993-1003","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Association of preoperative neutrophil\u2010to\u2010lymphocyte ratio with the risk of postoperative delirium in elderly patients undergoing noncardiac surgery: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"24","author":[{"given":"Bo","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology Hebei General Hospital  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Dong","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Hebei General Hospital  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Xu","sequence":"additional","affiliation":[{"name":"Dressing Room, Hebei General Hospital  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Hebei General Hospital  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6867-7825","authenticated-orcid":false,"given":"Jianli","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Hebei General Hospital  Shijiazhuang 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