{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T03:53:50Z","timestamp":1781495630990,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with Parkinson's disease (PD) suffer from serious quality of life problems. Diabetes has been demonstrated as an independent risk element for PD, aggravating its severity and accelerating its progression. There are currently no suitable biomarkers to reveal the impact of diabetes on PD. The purpose of our research was to study the impact of diabetes on PD using corneal confocal microscopy (CCM), a non\u2010invasive and objective test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fourteen PD patients with diabetes (PD\u2010DM), 60 PD patients without diabetes (PD\u2010NDM), and 30 healthy controls (HC) were included in the study. The clinical symptoms of patients with PD were assessed using the Unified Parkinson's Disease Rating Scale\u20103 (UPDRS\u20103) and the Parkinson's Disease Autonomic Symptom Prognosis Scale (SCOPA\u2010AUT). Participants underwent CCM to quantify the corneal nerve fibres.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Corneal nerve fibre density (CNFD) and corneal nerve fibre length (CNFL) in patients with PD were lower than HC. Furthermore, CNFD in PD\u2010DM was lower than in PD\u2010NDM (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01). We also assessed the relationship between CCM parameters and clinical scores. CNFL and Hamilton anxiety (HAMA) have a negative correlation (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.261,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.032), but this study did not observe a significant correlation between CCM parameters and SCOPA\u2010AUT. Additionally, CNFD could distinguish PD\u2010DM from PD\u2010NDM, achieving an area under the curve of 75.06% (95% CI, 61.76%\u201388.36%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The CCM could be served as an objective and sensitive biomarker to investigate the impact of diabetes in PD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/psyg.13187","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T02:48:25Z","timestamp":1724986105000},"page":"1267-1274","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Corneal nerve fibre loss as a marker to identify the impact of diabetes on Parkinson's disease"],"prefix":"10.1111","volume":"24","author":[{"given":"Xuebin","family":"Niu","sequence":"first","affiliation":[{"name":"Department of Neurology The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"},{"name":"Department of Neurology The First Clinical College, Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8521-0408","authenticated-orcid":false,"given":"Peixiao","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Neurology The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"},{"name":"Department of Neurology The First Clinical College, Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyue","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Neurology The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"},{"name":"Department of Neurology The First Clinical College, Xuzhou Medical University  Xuzhou 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Neurology The First Clinical College, Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7985-4912","authenticated-orcid":false,"given":"Kun","family":"Zan","sequence":"additional","affiliation":[{"name":"Department of Neurology The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"},{"name":"Department of Neurology The First Clinical College, Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-020-0111-7"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29122"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.14719"},{"key":"e_1_2_10_5_1","first-page":"1","volume-title":"13th International Conference 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