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Alzheimer's disease (AD) is the most prevalent type of dementia globally and a major contributor to disability and mortality in older individuals. Most notably, the neurological damage caused by AD is irreversible, but the current market still lacks effective medications for the treatment of dementia. Numerous research studies have indicated that the inflammatory response is significantly involved in the development of cognitive impairment, and elevated C\u2010reactive protein (CRP) levels in healthy people increases the likelihood of future AD. CRP is a nonspecific indicator of inflammation. In clinical practice, CRP has long been proven to be one of the risk factors and powerful predictors of neurodegenerative diseases. Given the accessibility and cost\u2010effectiveness of CRP testing, it is reasonable to anticipate its utilisation for early screening and monitoring the progression of AD in the future. This review therefore focuses on the specific relationship between CRP and various types of dementia and explores how CRP contributes to cognitive impairment.<\/jats:p>","DOI":"10.1111\/psyg.70032","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T21:44:40Z","timestamp":1744062280000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["C\u2010reactive protein\u2010mediated dementia"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5019-8977","authenticated-orcid":false,"given":"Jia\u2010Ming","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Neurology the Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Neurology the Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han\u2010Xiao","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology, the Wuxi No. 2 People's Hospital Affiliated Wuxi Clinical College of Nantong University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Qi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, the Wuxi No. 2 People's Hospital Affiliated Wuxi Clinical College of Nantong University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi\u2010Chen","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurology the Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University  Wuxi China"},{"name":"Department of Neurology, the Wuxi No. 2 People's Hospital Affiliated Wuxi Clinical College of Nantong University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Neurology the Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University  Wuxi China"},{"name":"Department of Neurology, the Wuxi No. 2 People's Hospital Affiliated Wuxi Clinical College of Nantong University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01296-0"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.06.012"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0021-9150(00)00586-4"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2020.577272"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14147"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/indianjpsychiatry.indianjpsychiatry_975_23"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.2559"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.17116\/jnevro202412409188"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21326"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60461-5"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30226-0"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(20)30185-7"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/610813"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101503"},{"key":"e_1_2_11_16_1","doi-asserted-by":"crossref","unstructured":"De Martinis M Franceschi C Monti Det al.Inflamm\u2010ageing and lifelong antigenic load as major determinants of ageing rate and longevity. 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