{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T01:57:13Z","timestamp":1781143033305,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T00:00:00Z","timestamp":1751673600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP24K10827"],"award-info":[{"award-number":["JP24K10827"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Progressive supranuclear palsy (PSP) is a four\u2010repeat tauopathy, and the differentiation of PSP from other neurodegenerative disorders is a common clinical problem. We applied a T1\u2010\/T2\u2010weighted ratio imaging technique based on standard clinical MRI to investigate PSP\u2010related changes in neuroimaging data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Twenty patients with PSP and 34 healthy participants underwent an examination to obtain T1\u2010 and T2\u2010weighted images at our hospital. We retrospectively computed each subject's T1\/T2\u2010weighted ratio index to use as a proxy for the brain's myelin content, and we analyzed the differences in the index values between the PSP and control groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our analysis revealed the precise differences in the T1\/T2\u2010weighted ratio index between the PSP and control groups and demonstrated that the patients with PSP showed significant reductions of the T1\/T2\u2010weighted ratio index in the midbrain, posterior commissure, caudate, thalamus, and bilateral insulae compared to the healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results show that the T1\/T2\u2010weighted ratio approach is useful to distinguish patients with PSP from healthy subjects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/psyg.70069","type":"journal-article","created":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T05:31:58Z","timestamp":1751693518000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Differences in the Regional\n                    <scp>T1<\/scp>\n                    \/\n                    <scp>T2<\/scp>\n                    \u2010Weighted Ratio Index Between Healthy Controls and Patients With Progressive Supranuclear Palsy"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8873-0822","authenticated-orcid":false,"given":"Miho","family":"Ota","sequence":"first","affiliation":[{"name":"Department of Radiology, National Center Hospital National Center of Neurology and Psychiatry  Tokyo Japan"},{"name":"Department of Neuropsychiatry University of Tsukuba  Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9305-7131","authenticated-orcid":false,"given":"Noriko","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Radiology, National Center Hospital National Center of Neurology and Psychiatry  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Neurology National Center Hospital, National Center of Neurology and Psychiatry  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Shigemoto","sequence":"additional","affiliation":[{"name":"Department of Radiology, National Center Hospital National Center of Neurology and Psychiatry  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Radiology, National Center Hospital National Center of Neurology and Psychiatry  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Maki","sequence":"additional","affiliation":[{"name":"Department of Radiology, National Center Hospital National Center of Neurology and Psychiatry  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Imokawa","sequence":"additional","affiliation":[{"name":"Department of Radiology, National Center Hospital National Center of Neurology and Psychiatry  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risa","family":"Kagaya","sequence":"additional","affiliation":[{"name":"Department of Radiology, National Center Hospital National Center of Neurology and Psychiatry  Tokyo 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