{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:21:43Z","timestamp":1773213703800,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["KAKENHI JP (24K18736)"],"award-info":[{"award-number":["KAKENHI JP (24K18736)"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    An 85\u2010year\u2010old woman with late\u2010onset depression subsequently developed persistent oral cenesthopathy. As antidepressant augmentation, low\u2010dose aripiprazole improved both mood and oral symptoms, but oversedation and parkinsonism necessitated tapering and discontinuation. After discontinuation, oral cenesthopathy recurred without clear depressive worsening. Dopamine transporter single\u2010photon emission computed tomography showed reduced bilateral striatal uptake and\n                    <jats:sup>123<\/jats:sup>\n                    I\u2010metaiodobenzylguanidine cardiac scintigraphy showed decreased uptake, with preserved cognition. In light of the clinical and imaging findings suggestive of dopaminergic dysfunction, and after an informed discussion of off\u2010label use, pramipexole 0.25\u2009mg daily was initiated. Oral discomfort lessened within 1\u2009week and oral intake normalised by 2\u2009weeks, without adverse effects; remission of oral symptoms and mood persisted for 6\u2009months. Overall, the presentation was conceptually compatible with the psychiatric\u2010onset phenotype described in the prodromal Lewy body disease research framework, but this remains an interpretive consideration rather than a diagnosis. Assessing possible dopaminergic involvement in similar cases of oral cenesthopathy may aid individualised management; however, the therapeutic role of dopamine agonists requires confirmation in prospective studies.\n                  <\/jats:p>","DOI":"10.1111\/psyg.70088","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T07:34:02Z","timestamp":1756280042000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Late\u2010Onset Oral Cenesthopathy With Dopaminergic Dysfunction: Therapeutic Response to Pramipexole in a Case With Suspected Prodromal Lewy Body Disease"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9268-2052","authenticated-orcid":false,"given":"Hitomi","family":"Matsui","sequence":"first","affiliation":[{"name":"Tokyo Metropolitan Institute for Geriatrics and Gerontology  Itabashi Japan"},{"name":"Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences Institute of Science Tokyo  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiro","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences Institute of Science Tokyo  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Kameyama","sequence":"additional","affiliation":[{"name":"Tokyo Metropolitan Institute for Geriatrics and Gerontology  Itabashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Omori","sequence":"additional","affiliation":[{"name":"Tokyo Metropolitan Institute for Geriatrics and Gerontology  Itabashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genichi","family":"Sugihara","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences Institute of Science Tokyo  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences Institute of Science Tokyo  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidehiko","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences Institute of Science Tokyo  Japan"},{"name":"Center for Brain Integration Research Institute of Science Tokyo  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ko","family":"Furuta","sequence":"additional","affiliation":[{"name":"Tokyo Metropolitan Institute for Geriatrics and Gerontology  Itabashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13030-016-0071-7"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/psyg.12015"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pcn5.171"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2022.09.010"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/psyg.13147"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009323"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215\u20100366(25)00194\u20104"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pcn5.70067"},{"key":"e_1_2_10_10_1","first-page":"497","article-title":"A Case of Oral Cenesthopathy Successfully Treated With Lithium Carbonate and Perospirone","volume":"23","author":"Kajitani K.","year":"2008","journal-title":"Seishinkei 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