{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:20:22Z","timestamp":1773213622054,"version":"3.50.1"},"reference-count":5,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T00:00:00Z","timestamp":1757808000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJSP2124"],"award-info":[{"award-number":["JPMJSP2124"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Semantic dementia (SD) is a type of dementia characterized by a loss of semantic memory, typically presenting with left\u2010predominant temporal lobe atrophy and a frontotemporal lobar degeneration with TDP\u201043 (FTLD\u2010TDP) type C pathology. However, atypical variants, such as those with a late\u2010onset or right\u2010predominant atrophy, exhibit considerable pathological diversity. We report an 81\u2010year\u2010old woman with atypical SD who presented with impaired naming, mild word comprehension deficits, and prosopagnosia. Brain MRI revealed right\u2010predominant atrophy in the amygdala, hippocampus, and anterior temporal lobes. Cerebrospinal fluid analysis showed a normal A\u03b2 level, suggesting a non\u2010Alzheimer's disease pathology. Tau PET imaging demonstrated a high signal in the right anterior temporal lobe, consistent with primary tauopathy. The patient's clinical presentation and imaging findings, particularly the atrophy in the amygdala and hippocampus, as well as the preserved communication ability, raised the possibility of argyrophilic grain disease (AGD) as the underlying pathology. This case highlights the importance of molecular imaging in diagnosing atypical SD. It suggests that AGD should be considered a possible underlying pathology for atypical SD cases, particularly those with late onset and right\u2010sided predominance. A longer follow\u2010up and eventual autopsy would be necessary to confirm the pathological diagnosis.<\/jats:p>","DOI":"10.1111\/psyg.70094","type":"journal-article","created":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T22:55:31Z","timestamp":1757890531000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Case of Late\u2010Onset Semantic Dementia With Right\u2010Predominant Temporal Lobe Atrophy due to Primary Tauopathy"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6150-9697","authenticated-orcid":false,"given":"Yuta","family":"Sudo","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine University of Tsukuba  Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0959-1499","authenticated-orcid":false,"given":"Masashi","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine University of Tsukuba  Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenjiro","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Doctoral Program in Medical Sciences, Graduate School of Comprehensive Human Sciences University of Tsukuba  Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8623-9829","authenticated-orcid":false,"given":"Kiyotaka","family":"Nemoto","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine University of Tsukuba  Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Yokota","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Tagai","sequence":"additional","affiliation":[{"name":"Advanced Neuroimaging Center Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3398-597X","authenticated-orcid":false,"given":"Hironobu","family":"Endo","sequence":"additional","affiliation":[{"name":"Advanced Neuroimaging Center Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiko","family":"Tokuda","sequence":"additional","affiliation":[{"name":"Advanced Neuroimaging Center Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Advanced Neuroimaging Center Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology  Chiba Japan"},{"name":"Neuroetiology and Diagnostic Science Osaka University Graduate School of Medicine  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Hatano","sequence":"additional","affiliation":[{"name":"Department of Applied Molecular Imaging, Faculty of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4355-3900","authenticated-orcid":false,"given":"Tetsuaki","family":"Arai","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine University of Tsukuba  Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-021-01229-z"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31821103e6"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12859"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp248"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-024-01828-6"}],"container-title":["Psychogeriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/psyg.70094","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/psyg.70094","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/am-pdf\/10.1111\/psyg.70094","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/psyg.70094","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T09:30:18Z","timestamp":1773135018000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/psyg.70094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":5,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/psyg.70094"],"URL":"https:\/\/doi.org\/10.1111\/psyg.70094","archive":["Portico"],"relation":{},"ISSN":["1346-3500","1479-8301"],"issn-type":[{"value":"1346-3500","type":"print"},{"value":"1479-8301","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2025-04-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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