{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T17:25:02Z","timestamp":1780507502997,"version":"3.54.1"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["18\/15571\u20107"],"award-info":[{"award-number":["18\/15571\u20107"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The relationship between neuropsychiatric symptoms (NPSs) and Alzheimer's disease (AD) pathophysiology, considering cerebrospinal fluid (CSF) biomarkers, is still not clarified and the available results in the literature are contradictory especially when it comes to the prodromic stages of AD. Clarifying the role of the AD biomarkers in the development of NPS in subjective cognitive decline (SCD) and mild cognitive impairment (MCI) is relevant and can be useful for planning longitudinal interventions in the AD continuum. The present work studies the correlation between NPSs and AD CSF biomarkers in SCD and MCI Brazilian subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a transversal study designed to evaluate the relationship between NPS and CSF AD biomarkers in SCD and MCI individuals. Voluntary participants were recruited through a virtually announced formulary. The inclusion criteria were age 55\u2009years or older, of both sexes, without distinction of ethnicity or socioeconomic status, the presence of cognitive complaints, and that were willing to participate in all research procedures. Exclusion criteria for all subjects included clinical dementia, other neurological or psychiatric diseases, traumatic brain injury that resulted in a loss of consciousness, drug or alcohol addiction, prior chronic exposure to neurotoxic substances, Fazekas scale \u2265\u20092, and a score on the Montreal Cognitive Assessment (MoCA) less than 17 points. All participants had Pfeffer's Functional Activities Questionnaire &lt;\u20095 and underwent medical and neuropsychological evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy\u2010one patients were included between 2019 and 2022, 54 with MCI and 17 with SCD. A significant correlation (\n                      <jats:italic>p<\/jats:italic>\n                      : 0.006) was observed between MBI\u2010C C domain and the concentrations of CSF amyloid\u2010beta peptide.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The study identified a significant correlation between domain C of the MBI\u2010C and CSF beta\u2010amyloid peptide analysing Brazilian patients with SCD and MCI. The results reinforce the hypothesis of the relationship between impulsivity symptoms and amyloid pathology. Further studies involving the correlations between MBI and neuropsychiatric symptoms with AD CSF biomarkers are necessary.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/psyg.70119","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T13:05:09Z","timestamp":1764680709000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impulse Dyscontrol Symptoms Are Related to Amyloid Beta in Patients With Subjective Cognitive Decline and Mild Cognitive Impairment"],"prefix":"10.1111","volume":"26","author":[{"given":"Ana Luiza Gon\u00e7alves","family":"Rochetti","sequence":"first","affiliation":[{"name":"School of Medical Sciences, UNICAMP\/SP  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isadora Cristina","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, UNICAMP\/SP  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1037-6047","authenticated-orcid":false,"given":"Lucas Luchesi","family":"Barnes","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, UNICAMP\/SP  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liara","family":"Rizzi","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, UNICAMP\/SP  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Italo Karmann","family":"Aventurato","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, UNICAMP\/SP  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda Costa","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, UNICAMP\/SP  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie Cristina Rocha","family":"da Silva","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, UNICAMP\/SP  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcio Luiz Figueredo","family":"Balthazar","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, UNICAMP\/SP  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,2]]},"reference":[{"issue":"1","key":"e_1_2_9_2_1","first-page":"1","article-title":"Agitation and Impulsivity in Mid and Late Life as Possible Risk Markers for Incident Dementia","volume":"6","author":"Bateman D. 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