{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:50:31Z","timestamp":1790704231208,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primary progressive aphasia (PPA) is a clinical syndrome characterized by progressive language impairment. The logopenic variant (lvPPA) is frequently associated with Alzheimer's disease (AD) pathology. With the approval of anti\u2010amyloid\u2010\u03b2 monoclonal antibodies, such as lecanemab and donanemab, for the treatment of AD, accurately differentiating lvPPA due to AD (lvAD) from the other PPA variants has become highly important.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirteen patients with PPA who underwent cognitive testing, including the Standard Language Test of Aphasia (SLTA), brain magnetic resonance imaging, single\u2010photon emission computed tomography (SPECT), cerebrospinal fluid (CSF) biomarker analysis, and amyloid positron emission tomography (PET) imaging were enrolled in this study. Patients were classified into the lvPPA, semantic variant PPA (svPPA), and nonfluent\/agrammatic variant PPA (nfaPPA) groups based on the results of clinical and neuropsychological assessments. We determined the proportion of PPA patients in each group who met the optimal use guidelines for anti\u2010amyloid monoclonal antibody therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Six (86%) of the 7 lvPPA patients were amyloid positive (A+), and 5 (71%) were eligible for lecanemab or donanemab. In most lvPPA patients, SPECT displayed an AD\u2010typical pattern of hypoperfusion in the bilateral temporoparietal regions, posterior cingulate gyrus, and precuneus. One lvPPA patient was negative for AD biomarkers and demonstrated an atypical perfusion pattern for AD, and was subsequently rediagnosed as having frontotemporal lobar degeneration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results suggest that SPECT may play a supportive role in differentiating lvAD from PPA. In the current clinical era of anti\u2013amyloid\u2010\u03b2 monoclonal antibody therapy, accurate identification of lvAD among patients with language\u2010predominant symptoms is increasingly important. Larger studies should be performed in the near future to validate these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/psyg.70152","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:20Z","timestamp":1773014420000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Eligibility for Anti\u2010Amyloid\u2010\u03b2 Monoclonal Antibodies in Patients With Primary Progressive Aphasia due to Alzheimer's Disease in Japan"],"prefix":"10.1111","volume":"26","author":[{"given":"Shoya","family":"Inagawa","sequence":"first","affiliation":[{"name":"Department of Geriatric Medicine Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Inagawa","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akito","family":"Tsugawa","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Takenoshita","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5854-2070","authenticated-orcid":false,"given":"Kazuhiro","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Radiology Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Ishii","sequence":"additional","affiliation":[{"name":"Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensaku","family":"Kasuga","sequence":"additional","affiliation":[{"name":"Brain Research Institute, Niigata University  Niigata Japan"},{"name":"Department of Diagnostic Innovation Science National Center for Geriatrics and Gerontology  Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8828-8085","authenticated-orcid":false,"given":"Takeshi","family":"Ikeuchi","sequence":"additional","affiliation":[{"name":"Brain Research Institute, Niigata University  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichiro","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410110607"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31821103e6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25333"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2100708"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13092"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1044\/jshd.4503.308"},{"key":"e_1_2_9_9_1","volume-title":"Western Aphasia Battery: Japanese Version","author":"Sugishita M.","year":"1986"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.11477\/mf.1416201600"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10825"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandl.2012.04.005"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2023.03.007"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjno\u20102022\u2010000321"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_2_9_16_1","unstructured":"Ministry of Health LaWJ \u201cOptimal Use Guidelines for Anti\u2010Amyloid \u03b2 Monoclonal Antibody Lecanemab and Donanemab \u201dhttps:\/\/www.mhlw.go.jp\/content\/12404000\/001178607.pdf."},{"key":"e_1_2_9_17_1","unstructured":"Neurology. 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