{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:48:04Z","timestamp":1787240884540,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T00:00:00Z","timestamp":1774051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T00:00:00Z","timestamp":1774051200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100021135","name":"Toshiaki Ogasawara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100021135","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>With the advent of disease\u2010modifying therapies for Alzheimer's disease, there is a growing demand for more cost\u2010effective methods that predict amyloid PET positivity. In Japan, the combination of structural brain MRI and regional cerebral blood flow (rCBF) single\u2010photon emission computed tomography (rCBF SPECT) is routinely used in clinical practice for neuroimaging. The present study investigated the utility of this imaging approach for amyloid PET positivity in real\u2010world clinical settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis of 101 patients who visited the Memory Clinic at Juntendo University Hospital between April 2019 and September 2023 was performed. All patients had undergone amyloid PET imaging at their own expense, in addition to a neuropsychological assessment, structural brain MRI and rCBF SPECT. Among 58 cases that underwent a voxel\u2010based specific regional analysis system for Alzheimer's disease (VSRAD), volumetric differences between the amyloid\u2010positive and \u2010negative groups were assessed using Statistical Parametric Mapping (SPM) version 12.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 101 patients analysed, 68 were positive and 33 were negative for amyloid. Twenty\u2010nine patients had a change in clinical diagnosis after amyloid PET imaging, which affected subsequent management. Using VSRAD, VOI severity (continuous value) was set to 0.95 based on Youden's index and AUC (95% CI) was 0.72 (0.572\u20130.867), with a sensitivity of 90%, specificity of 52% and accuracy of 78%. In the visual assessment, MRI and rCBF SPECT were combined, and AUC (95% CI) was 0.767 (0.629\u20130.905), with a sensitivity decrease to 21% and specificity increase to 95%. The SPM12 analysis revealed clusters in the right medial temporal lobe at an uncorrected threshold (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). However, no voxels survived family\u2010wise error (FWE) correction (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A VSRAD analysis of brain MRI has moderate discriminatory ability as a screening tool for predicting amyloid PET positivity. The addition of SPECT to MRI was not associated with a statistically significant improvement compared with MRI alone. SPECT may contribute to the differential diagnosis of non\u2010Alzheimer's disease. MRI alone could be considered an option to increase the pre\u2010test probability of amyloid PET positivity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/psyg.70158","type":"journal-article","created":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T08:31:09Z","timestamp":1774081869000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Utility of Regional Cerebral Blood Flow\n                    <scp>SPECT<\/scp>\n                    and\n                    <scp>MRI<\/scp>\n                    for Predicting Amyloid Deposition in Real\u2010World Clinical Settings"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9214-1983","authenticated-orcid":false,"given":"Toshiki","family":"Takayama","sequence":"first","affiliation":[{"name":"The Medical Center for Dementia, Juntendo Hospital  Tokyo Japan"},{"name":"Department of Psychiatry Juntendo University  Tokyo 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