{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:12:27Z","timestamp":1778634747265,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Semantic dementia (SD) is a type of frontotemporal dementia primarily characterised by semantic aphasia, which involves the loss of meaning of words and objects. In SD, the pattern of alteration in the regional T1\/T2\u2010weighted ratio index, a proxy for myelin content, remains to be clarified. The present study examined the regional changes in the T1\/T2\u2010weighted ratio index associated with SD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Nineteen patients with SD and 21 healthy participants underwent a 1.5\u2010Tesla magnetic resonance imaging scan. Differences in index values between the two diagnostic groups were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients with SD had significantly reduced index values in bilateral temporal poles and nuclei accumbens. A significant positive relationship was found between the index values in the left parahippocampal region and the \u2018naming\u2019 subscore in the Mini\u2010Mental State Examination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results suggest that the T1\/T2\u2010weighted ratio approach is useful for differentiating the patients with SD from healthy participants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/psyg.70170","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T14:36:17Z","timestamp":1777041377000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Changes in Regional\n                    <scp>T1<\/scp>\n                    \/\n                    <scp>T2<\/scp>\n                    \u2010Weighted Ratio Index in Patients With Semantic Dementia"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8873-0822","authenticated-orcid":false,"given":"Miho","family":"Ota","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Division of Clinical Medicine, Institute of Medicine University of Tsukuba  Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Koshibe","sequence":"additional","affiliation":[{"name":"University of Tsukuba Hospital  Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayako","family":"Kitabatake","sequence":"additional","affiliation":[{"name":"University of Tsukuba Hospital  Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takumi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Division of Clinical Medicine, Institute of Medicine University of Tsukuba  Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8623-9829","authenticated-orcid":false,"given":"Kiyotaka","family":"Nemoto","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics and Management and Psychiatry, Institute of Medicine University of Tsukuba  Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuaki","family":"Arai","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Division of Clinical Medicine, Institute of Medicine University of Tsukuba  Ibaraki 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