{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T09:07:12Z","timestamp":1789549632215,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["TK21K15730"],"award-info":[{"award-number":["TK21K15730"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008667","name":"SENSHIN Medical Research Foundation","doi-asserted-by":"publisher","award":["Overseas Study grant"],"award-info":[{"award-number":["Overseas Study grant"]}],"id":[{"id":"10.13039\/501100008667","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Very late\u2010onset schizophrenia\u2010like psychosis (VLOSLP) is clinically heterogeneous, and its relationship with dementia\u2010related neurodegenerative disease remains unresolved. We examined whether Alzheimer's disease (AD) and Lewy body disease (LBD) biomarker status were associated with dementia progression in VLOSLP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively identified patients who visited the University of Osaka Hospital between January 2018 and December 2023 and met criteria for VLOSLP. Twenty\u2010two participants with AD and\/or LBD biomarker data and at least one follow\u2010up assessment within 775\u2009days were classified as biomarker\u2010negative (BMs\u2010neg;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097) or biomarker\u2010positive (BMs\u2010pos;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200915). Group comparisons were performed using Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      tests and Fisher's exact tests.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The BMs\u2010pos group showed older onset age and lower memory scores than the BMs\u2010neg group. Dementia progression was more frequent in the BMs\u2010pos group than in the BMs\u2010neg group, although the difference was not statistically significant (8\/15 [53.3%] vs. 1\/7 [14.3%];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.165; odds ratio 6.31; 95% CI 0.55\u2013353.18). Five of eight participants with AD biomarker positivity progressed to AD dementia. Three of seven participants with LBD biomarker positivity progressed to dementia, including two diagnosed with dementia with Lewy bodies. Follow\u2010up MMSE, CDR, and CDR\u2010SB scores differed significantly between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>AD and\/or LBD biomarker\u2010positive VLOSLP may be associated with greater dementia progression and cognitive decline, although findings should be interpreted cautiously given the small sample size and retrospective design. These results support the clinical value of considering neurodegenerative biomarkers when evaluating the prognosis and underlying pathology of VLOSLP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/psyg.70205","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T02:42:57Z","timestamp":1786416177000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Progression to Dementia in Very Late\u2010Onset Schizophrenia\u2010Like Psychosis Stratified by\n                    <scp>A<\/scp>\n                    lzheimer's Disease and\n                    <scp>L<\/scp>\n                    ewy Body Disease Biomarkers: A Retrospective Cohort Study"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9350-3162","authenticated-orcid":false,"given":"Yuto","family":"Satake","sequence":"first","affiliation":[{"name":"Department of Psychiatry The University of Osaka Graduate School of Medicine  Suita Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3662-1469","authenticated-orcid":false,"given":"Hideki","family":"Kanemoto","sequence":"additional","affiliation":[{"name":"Department of Psychiatry The University of Osaka Graduate School of Medicine  Suita Osaka Japan"},{"name":"Health and Counseling Center The University of Osaka  Toyonaka Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0578-2517","authenticated-orcid":false,"given":"Daiki","family":"Taomoto","sequence":"additional","affiliation":[{"name":"Department of Psychiatry The University of Osaka Graduate School of Medicine  Suita Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5686-4084","authenticated-orcid":false,"given":"Kayo","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Psychiatry The University of Osaka Graduate School of Medicine  Suita Osaka Japan"},{"name":"Department of Psychiatry Osaka Psychiatric Medical Center  Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7289-7818","authenticated-orcid":false,"given":"Shigeki","family":"Katakami","sequence":"additional","affiliation":[{"name":"Department of Psychiatry The University of Osaka Graduate School of Medicine  Suita Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1911-9510","authenticated-orcid":false,"given":"Matasaburo","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry The University of Osaka Graduate School of Medicine  Suita Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Matsunaga","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Osaka 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