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Studying the efficacy of potential interventions in clinical populations is challenging, creating a need for paradigms within which candidate reconsolidation\u2010blocking interventions can be readily tested. We used videos of biologically prepared conditioned stimuli (tarantulas) to test the efficacy of propranolol in blocking reconsolidation of conditioned fear in healthy young adults. Strong differential conditioning, measured by skin conductance, was observed among a screened subset of participants during acquisition. However, subsequent propranolol failed to reduce reactivity to the reactivated conditioned stimulus. These results are consistent with other recent findings and point to a need for testing other candidate drugs.<\/jats:p>","DOI":"10.1111\/psyp.12326","type":"journal-article","created":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T05:00:55Z","timestamp":1410843655000},"page":"407-415","source":"Crossref","is-referenced-by-count":28,"title":["Prereactivation propranolol fails to reduce skin conductance reactivity to prepared fear\u2010conditioned stimuli"],"prefix":"10.1111","volume":"52","author":[{"given":"Justin D.","family":"Spring","sequence":"first","affiliation":[{"name":"Department of Psychiatry Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nellie E.","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Mueller\u2010Pfeiffer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Psychiatry and Psychotherapy University Hospital Zurich  Zurich Switzerland"},{"name":"Center of Education and Research (COEUR) Psychiatric Services of the County of St. Gallen\u2010North  Wil Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed R.","family":"Milad","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger K.","family":"Pitman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott P.","family":"Orr","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1223006"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20104614\u20101126\u20100"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469\u20108986.2012.01384.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.1990.tb01966.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2007.05.006"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/070674371405900408"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.08.018"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.psych.55.090902.142050"},{"key":"e_1_2_5_10_1","first-page":"1","volume-title":"Methods in psychophysiology","author":"Edelberg R.","year":"1967"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.1994.tb02446.x"},{"key":"e_1_2_5_12_1","volume-title":"Structured Clinical Interview for DSM\u2010IV\u2010TR Axis I Disorders, research version, non\u2010patient edition (SCID\u2010I\/NP)","author":"First M. 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