{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T19:50:53Z","timestamp":1759693853996},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,9,14]],"date-time":"2014-09-14T00:00:00Z","timestamp":1410652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychophysiology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Levels of 3\u2010methoxy\u20104\u2010hydroxyphenylglycol (<jats:styled-content style=\"fixed-case\">MHPG<\/jats:styled-content>) may reflect central noradrenergic activity. In this study, we investigated salivary <jats:styled-content style=\"fixed-case\">MHPG<\/jats:styled-content> changes after awakening, and explored their relationships with cortisol and peripheral autonomic activity. The participants were 25 college students. Saliva samples were collected on awakening and 30\u2009min after awakening to determine <jats:styled-content style=\"fixed-case\">MHPG<\/jats:styled-content> and cortisol. Ambulatory electrocardiograms were obtained to assess heart rate, cardiac sympathetic index (<jats:styled-content style=\"fixed-case\">CSI<\/jats:styled-content>), and cardiac vagal index (<jats:styled-content style=\"fixed-case\">CVI<\/jats:styled-content>) before and after awakening. <jats:styled-content style=\"fixed-case\">MHPG<\/jats:styled-content> levels increased significantly during the first 30\u2009min after awakening. Similarly, cortisol, heart rate, and <jats:styled-content style=\"fixed-case\">CSI<\/jats:styled-content> increased during the 30\u2009min after awakening, but changes in <jats:styled-content style=\"fixed-case\">MHPG<\/jats:styled-content> did not correlate with changes in cortisol, heart rate, <jats:styled-content style=\"fixed-case\">CSI<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">CVI<\/jats:styled-content> during that period. This study demonstrated that salivary <jats:styled-content style=\"fixed-case\">MHPG<\/jats:styled-content> levels increase after awakening, in common with cortisol, heart rate, and cardiac sympathetic activity.<\/jats:p>","DOI":"10.1111\/psyp.12330","type":"journal-article","created":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T01:42:09Z","timestamp":1410745329000},"page":"425-428","source":"Crossref","is-referenced-by-count":6,"title":["Salivary 3\u2010methoxy\u20104\u2010hydroxyphenylglycol increases after awakening in healthy young adults"],"prefix":"10.1111","volume":"52","author":[{"given":"Nagisa","family":"Sugaya","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Public Health Graduate School of Medicine Yokohama City University  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhei","family":"Izawa","sequence":"additional","affiliation":[{"name":"Health Administration and Psychosocial Factor Research Group National Institute of Occupational Safety and Health  Kawasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuichiro","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Division of Clinical Psychology Health Care and Special Support Graduate School of Education Joetsu University of Education  Joetsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Namiko","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Graduate School of Human Sciences Waseda University  Tokorozawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jumpei","family":"Yajima","sequence":"additional","affiliation":[{"name":"Department of Human Studies Beppu University  Beppu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisayoshi","family":"Okamura","sequence":"additional","affiliation":[{"name":"Cognitive and Molecular Research Institute of Brain Diseases Kurume University  Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Horiuchi","sequence":"additional","affiliation":[{"name":"Japan Society for the Promotion of Science  Tokyo Japan"},{"name":"Health Sciences University of Hokkaido  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Tsuda","sequence":"additional","affiliation":[{"name":"Faculty of Literature Kurume University  Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinobu","family":"Nomura","sequence":"additional","affiliation":[{"name":"Faculty of Human Sciences Waseda University  Tokorozawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,14]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881106075274"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2008.10.004"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.02.041"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440\u20101681.1991.tb01399.x"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/10253890.2011.648247"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2006.06.003"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301\u20100082(86)90008\u20100"},{"key":"e_1_2_4_9_1","unstructured":"Ministry of Health Labour and Welfare of Japan. 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