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Although the constructs in the RDoC system are characterized in \u201cprocess terms\u201d (i.e., as functional concepts with brain and behavioral referents), these constructs can also be framed as dispositions (i.e., as dimensions of variation in biobehavioral functioning across individuals). Focusing on one key RDoC construct, acute threat or \u201cfear,\u201d the current article illustrates a construct\u2010oriented <jats:italic>psychoneurometric<\/jats:italic> strategy for operationalizing this construct in individual difference terms\u2014as threat sensitivity (THT+). Utilizing data from 454 adult participants, we demonstrate empirically that (a) a scale measure of THT+ designed to tap general fear\/fearlessness predicts effectively to relevant clinical problems (i.e., fear disorder symptoms), (b) this scale measure shows reliable associations with physiological indices of acute reactivity to aversive visual stimuli, and (c) a cross\u2010domain factor reflecting the intersection of scale and physiological indicators of THT+ predicts effectively to both clinical and neurophysiological criterion measures. Results illustrate how the psychoneurometric approach can be used to create a dimensional index of a biobehavioral trait construct, in this case THT+, which can serve as a bridge between phenomena in domains of psychopathology and neurobiology. Implications and future directions are discussed with reference to the RDoC initiative and existing report\u2010based conceptions of psychological traits.<\/jats:p>","DOI":"10.1111\/psyp.12512","type":"journal-article","created":{"date-parts":[[2016,2,15]],"date-time":"2016-02-15T17:37:35Z","timestamp":1455557855000},"page":"393-405","source":"Crossref","is-referenced-by-count":86,"title":["Psychoneurometric operationalization of threat sensitivity: Relations with clinical symptom and physiological response criteria"],"prefix":"10.1111","volume":"53","author":[{"given":"James R.","family":"Yancey","sequence":"first","affiliation":[{"name":"Florida State University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noah C.","family":"Venables","sequence":"additional","affiliation":[{"name":"Florida State University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"Patrick","sequence":"additional","affiliation":[{"name":"Florida State University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,15]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Personality: A psychological interpretation","author":"Allport G. 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