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A rapidly accumulating array of transdiagnostic commonalities, across multiple objective and subjective measures, underscores the clear potential of this initiative. At the same time, a road map for guiding future RDoC research efforts is needed that draws upon the wealth of extant disorder\u2010specific findings. In this issue, Hamm and colleagues provide an example of conceptualizing within\u2010disorder processes in terms of dimensional brain\u2010behavior relationships that advances the understanding of panic disorder with agoraphobia beyond the conventional nosological framework. 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