{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:21:26Z","timestamp":1787016086596,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T00:00:00Z","timestamp":1456876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychophysiology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Physiologic investigations of generalized anxiety disorder (GAD) have skewed toward assessment of the autonomic nervous system, largely neglecting hypothalamic\u2010pituitary\u2010adrenal (HPA) axis variables. Although these systems coordinate\u2014suggesting a degree of symmetry\u2014to promote adaptive functioning, most studies opt to monitor either one system or the other. Using a ratio of salivary alpha\u2010amylase (sAA) over salivary cortisol, the present study examined symmetry between the sympathetic nervous system (SNS) and HPA axis in individuals with GAD (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200971) and healthy controls (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200937). Compared to healthy controls, individuals with GAD exhibited greater baseline ratios of sAA\/cortisol and smaller ratios of sAA\/cortisol following a mental arithmetic challenge. We propose that the present study provides evidence for SNS\u2010HPA asymmetry in GAD. Further, these results suggest that increased SNS suppression in GAD may be partially mediated by cortisol activity.\n                  <\/jats:p>","DOI":"10.1111\/psyp.12634","type":"journal-article","created":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T09:57:50Z","timestamp":1456912670000},"page":"951-957","source":"Crossref","is-referenced-by-count":43,"title":["Sympathetic and hypothalamic\u2010pituitary\u2010adrenal asymmetry in generalized anxiety disorder"],"prefix":"10.1111","volume":"53","author":[{"given":"Jonathan W.","family":"Reeves","sequence":"first","affiliation":[{"name":"Department of Psychology University of California, Berkeley Berkeley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron J.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Psychology University of California, Berkeley Berkeley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle G.","family":"Newman","sequence":"additional","affiliation":[{"name":"Department of Psychology The Pennsylvania State University State College Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas A.","family":"Granger","sequence":"additional","affiliation":[{"name":"Institute for Interdisciplinary Salivary Bioscience Research, Arizona State University Tempe Arizona USA"},{"name":"Johns Hopkins University School of Nursing Baltimore Maryland USA"},{"name":"Johns Hopkins University Bloomberg School of Public Health Baltimore Maryland USA"},{"name":"John Hopkins University School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2011.10.003"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2011.06.008"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psycneuen.2013.02.010"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004703-200204000-00007"},{"key":"e_1_2_5_6_1","volume-title":"Anxiety and its disorders: The nature and treatment of anxiety and panic","author":"Barlow D. 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