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Parents' perceived stress has been linked to decreased hippocampal volume in young children. However, no studies have investigated the links between self\u2010perceived stress and brain structure or function in adolescents. Additionally, findings from previous research with younger or older samples are inconsistent, likely in part due to inconsistencies in participants' age range. In this study, we investigated the associations among self\u2010perceived stress, family socioeconomic factors (family income, parental education), subcortical (hippocampus, amygdala) volumes, prefrontal cortical thickness and surface area, and memory and executive functioning performance in adolescents. One hundred and forty\u2010three participants (12\u201320 years old) were administered a cognitive battery, a questionnaire to assess perceived stress, and a structural MRI scan. Higher levels of perceived stress were associated with decreased adolescent hippocampal volume. This study provides empirical evidence of how experience may shape brain development in adolescence\u2014a period of plasticity during which it may be possible to intervene and prevent negative developmental outcomes.<\/jats:p>","DOI":"10.1111\/psyp.13025","type":"journal-article","created":{"date-parts":[[2017,10,20]],"date-time":"2017-10-20T13:46:41Z","timestamp":1508507201000},"source":"Crossref","is-referenced-by-count":48,"title":["Perceived stress is associated with smaller hippocampal volume in adolescence"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2826-4561","authenticated-orcid":false,"given":"Luciane R.","family":"Piccolo","sequence":"first","affiliation":[{"name":"Teachers College Columbia University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly G.","family":"Noble","sequence":"additional","affiliation":[{"name":"Teachers College Columbia University New York New York 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