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We first outline a functional perspective on Pavlovian conditioning and provide a general introduction and historical background on interoceptive conditioning as a special instance of Pavlovian conditioning. Next, biological and learning accounts of panic disorder are discussed, followed by an analysis of which stimuli and responses may be most promising to model learning that is relevant to panic disorder. Finally, studies on interoceptive fear conditioning with respiratory stimuli are reviewed and discussed, and future directions are outlined.<\/jats:p>","DOI":"10.1111\/psyp.13421","type":"journal-article","created":{"date-parts":[[2019,6,22]],"date-time":"2019-06-22T12:31:02Z","timestamp":1561206662000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Interoception, conditioning, and fear: The panic threesome"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0048-774X","authenticated-orcid":false,"given":"Ilse","family":"Van Diest","sequence":"first","affiliation":[{"name":"Health, Behavior &amp; Psychopathology, Faculty of Psychology &amp; Educational Sciences University of Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beth.2011.06.001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2007.04.008"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2010.03.004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/psyp.12295"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(01)00075-0"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.20048"},{"key":"e_1_2_8_8_1","volume-title":"Anxiety and its disorders: The nature and treatment of anxiety and panic","author":"Barlow D. 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