{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T17:59:21Z","timestamp":1768586361572,"version":"3.49.0"},"reference-count":52,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T00:00:00Z","timestamp":1566259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR50969"],"award-info":[{"award-number":["AR50969"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["561-00436"],"award-info":[{"award-number":["561-00436"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["IK2 CX001679"],"award-info":[{"award-number":["IK2 CX001679"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychophysiology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anticipation of a painful experience can influence brain activity and increase sensitivity to experimental somatosensory stimuli in healthy adults, but this response is poorly understood among individuals with chronic musculoskeletal pain (CMP). Studies of brain and perceptual responses to somatosensory stimuli are used to make inferences about central nervous system dysfunction as a potential mechanism of symptoms. As such, we sought to (a) determine the influence of pain anticipation on pain\u2010relevant brain regions and pain perception, and (b) characterize potential differences in these responses between Gulf War Veterans with CMP and matched healthy control (CO) Veterans. CMP (<jats:italic>N<\/jats:italic>\u00a0=\u00a030) and CO Veterans (<jats:italic>N<\/jats:italic>\u00a0=\u00a031) were randomized to conditions designed to generate expectations that either painful (pain) or nonpainful (no pain) stimuli would be administered. Brain responses to five nonpainful thermal stimuli were measured during fMRI, and each stimulus was rated for pain intensity and unpleasantness. In the pain condition, an incremental linear decrease in activity across stimuli was observed in the posterior cingulate cortex, cingulate cortex, and middle temporal gyrus. Further, in the pain condition, differential responses were observed between CMP and CO Veterans in the middle temporal gyrus. These findings indicate that brain responses to nonpainful thermal stimuli in Veterans with CMP are sensitive to pain anticipation, and we recommend accounting for the influence of pain anticipation in future investigations of central nervous system dysfunction in CMP.<\/jats:p>","DOI":"10.1111\/psyp.13452","type":"journal-article","created":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T13:11:38Z","timestamp":1566306698000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Influence of pain anticipation on brain activity and pain perception in Gulf War Veterans with chronic musculoskeletal pain"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1581-3210","authenticated-orcid":false,"given":"Jacob B.","family":"Lindheimer","sequence":"first","affiliation":[{"name":"William S. Middleton Memorial Veterans Hospital Madison Wisconsin"},{"name":"Department of Kinesiology University of Wisconsin\u2010Madison Madison Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron J.","family":"Stegner","sequence":"additional","affiliation":[{"name":"William S. Middleton Memorial Veterans Hospital Madison Wisconsin"},{"name":"Department of Kinesiology University of Wisconsin\u2010Madison Madison Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura D.","family":"Ellingson\u2010Sayen","sequence":"additional","affiliation":[{"name":"Department of Kinesiology Iowa State University Ames Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie M.","family":"Van Riper","sequence":"additional","affiliation":[{"name":"William S. Middleton Memorial Veterans Hospital Madison Wisconsin"},{"name":"Department of Kinesiology University of Wisconsin\u2010Madison Madison Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan J.","family":"Dougherty","sequence":"additional","affiliation":[{"name":"William S. Middleton Memorial Veterans Hospital Madison Wisconsin"},{"name":"Department of Kinesiology University of Wisconsin\u2010Madison Madison Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Falvo","sequence":"additional","affiliation":[{"name":"Department of Veterans Affairs, NJ Health Care System War Related Illness and Injury Study Center East Orange New Jersey"},{"name":"New Jersey Medical School Rutgers Biomedical and Health Sciences Newark New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dane B.","family":"Cook","sequence":"additional","affiliation":[{"name":"William S. Middleton Memorial Veterans Hospital Madison Wisconsin"},{"name":"Department of Kinesiology University of Wisconsin\u2010Madison Madison Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0057-10.2010"},{"key":"e_1_2_6_3_1","volume-title":"Beck Depression Inventory manual","author":"Beck A. T.","year":"1996"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0b013e318236588a"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.112.1.155"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-014-0419-2"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.02.006"},{"issue":"2","key":"e_1_2_6_8_1","first-page":"364","article-title":"Functional imaging of pain in patients with primary fibromyalgia","volume":"31","author":"Cook D. B.","year":"2004","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2009.11.010"},{"issue":"308","key":"e_1_2_6_10_1","first-page":"1","article-title":"Placebo and nocebo effects: The advantage of measuring expectations and psychological factors","volume":"8","author":"Corsi N.","year":"2017","journal-title":"Frontiers in Psychology"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.MSS.0000078924.61453.FB"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0013164401614002"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/JOM.0000000000000627"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2011.11.001"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci6010008"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2017.05.013"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0024338"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2017.12.260"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2012.01.014"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh098"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(87)91034-7"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(78)90020-9"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10225"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2007.07.006"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38905"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043764-200005000-00006"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4463-05.2006"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.irn.2018.01.003"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2944-08.2008"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.11.008"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.01.021"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20213"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408576102"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.3758\/s13428-019-01246-w"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2010.12.004"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21910"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S60433"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22727"},{"key":"e_1_2_6_39_1","volume-title":"R: A language and environment for statistical computing","author":"R Core Team","year":"2013"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2015.10.010"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsw181"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-19-07438.2000"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.09.018"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwu240"},{"key":"e_1_2_6_45_1","volume-title":"Manual for the State\u2010Trait Anxiety Inventory","author":"Spielberger C. D.","year":"1983"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1037\/1040-3590.7.4.524"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.08.053"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.07.012"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001038"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199206000-00002"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2087-10.2010"},{"key":"e_1_2_6_52_1","volume-title":"Introduction to robust estimation and hypothesis testing","author":"Wilcox R.","year":"2017"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1080\/02664763.2010.498507"}],"container-title":["Psychophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpsyp.13452","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/psyp.13452","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/psyp.13452","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/psyp.13452","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T03:25:03Z","timestamp":1694229903000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/psyp.13452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,20]]},"references-count":52,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1111\/psyp.13452"],"URL":"https:\/\/doi.org\/10.1111\/psyp.13452","archive":["Portico"],"relation":{},"ISSN":["0048-5772","1469-8986"],"issn-type":[{"value":"0048-5772","type":"print"},{"value":"1469-8986","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,20]]},"assertion":[{"value":"2018-08-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13452"}}