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Although there are extensive findings connecting low cortisol to psychopathy, less support has emerged for high levels of testosterone. This study examined whether incorporating the HPG hormone, estradiol, into this model would reveal relationships in line with theory: high levels of estradiol and testosterone in combination with low levels of cortisol would inform psychopathic traits. Baseline and reactive hormone levels were measured and compared to Psychopathy Checklist\u2010Youth Version (PCL\u2010YV) interviews among 66 male justice\u2010involved youth (<jats:italic>M<\/jats:italic> age\u00a0=\u00a015.73) in a Southeastern juvenile detention center. The primary findings of this study were relationships between interacting HPA and HPG axis hormones with facet one and facet two psychopathic traits. Specifically, psychopathy total scores, interpersonal traits, and affective traits related to estradiol and testosterone reactivity, in that psychopathy scores were more likely with decreases in hormone reactivity (i.e., change in hormone level) following a stressor. Moreover, affective traits related to reactivity in all three hormones. These findings support inclusion of estradiol in neurobiological models of psychopathy and consideration of the individual components of psychopathy. This study adds to the growing body of research supporting interactions between variations in functioning of the HPA and HPG axes in relation to psychopathy.<\/jats:p>","DOI":"10.1111\/psyp.13694","type":"journal-article","created":{"date-parts":[[2020,10,11]],"date-time":"2020-10-11T14:45:05Z","timestamp":1602427505000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Reconsidering the role of sex hormones in psychopathy development: Estrogen and psychopathy among male justice\u2010involved youth"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4497-7791","authenticated-orcid":false,"given":"Natalie A.","family":"Harrison","sequence":"first","affiliation":[{"name":"Department of Psychology The University of Alabama Tuscaloosa AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3046-3455","authenticated-orcid":false,"given":"Ryan L.","family":"Earley","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences The University of Alabama Tuscaloosa AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall T.","family":"Salekin","sequence":"additional","affiliation":[{"name":"Department of Psychology The University of Alabama Tuscaloosa AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,11]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Multiple regression: Testing and interpreting interactions","author":"Aiken L. 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