{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:13:32Z","timestamp":1790349212107,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,11]],"date-time":"2020-10-11T00:00:00Z","timestamp":1602374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["UL1RR025755"],"award-info":[{"award-number":["UL1RR025755"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD061644"],"award-info":[{"award-number":["HD061644"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD067670"],"award-info":[{"award-number":["HD067670"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["8UL1TR000090\u201005"],"award-info":[{"award-number":["8UL1TR000090\u201005"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychophysiology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Significant health disparities exist between African Americans (AA) and European Americans (EA) in hypertension and hypertension\u2010related disorders. Evidence suggests that this is due to impaired vasodilation in AAs. Pregnancy is a potent systemic vasodilatory state. However, differences in vasodilation between AAs and EAs have not been investigated in pregnancy. We sought to examine the effects of pregnancy on vasodilation in AA and EA women and how this might be related to discrimination and low birth weight in their offspring. Hemodynamics [blood pressure (MAP), cardiac output (CO), total peripheral resistance (TPR)] and heart rate variability (HF\u2010HRV) were examined at baseline in 40 pregnant AAs (<jats:italic>n<\/jats:italic>\u00a0=\u00a020) and EAs (<jats:italic>n<\/jats:italic>\u00a0=\u00a020) and matched nonpregnant women (<jats:italic>n<\/jats:italic>\u00a0=\u00a040). The Experiences of Discrimination scale and birth weight were also measured in the offspring of the pregnant participants. Whereas pregnancy was associated with decreased MAP independent of race, AAs showed impaired vasodilation independent of pregnancy status as indicated by greater TPR despite greater HF\u2010HRV. In AAs, but not EAs, reports of fewer incidences of discrimination were associated with greater TPR. Finally, the HF\u2010HRV of EA mothers was inversely related to the birth weight of their offspring but was uncorrelated in AAs. We report novel evidence of impaired vasodilation to an endogenous vasodilatory stimulus in AAs. Higher TPR was related to discrimination in AAs and higher HF\u2010HRV was related to low birth weight in EAs. These findings have implications for understanding the intergenerational transmission of impaired vasodilation in AAs.<\/jats:p>","DOI":"10.1111\/psyp.13699","type":"journal-article","created":{"date-parts":[[2020,10,11]],"date-time":"2020-10-11T14:40:05Z","timestamp":1602427205000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Impaired vasodilation in pregnant African Americans: Preliminary evidence of potential antecedents and consequences"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5571-050X","authenticated-orcid":false,"given":"Lisa M.","family":"Christian","sequence":"first","affiliation":[{"name":"Department of Psychiatry &amp; Behavioral Health The Ohio State University Wexner Medical Center Columbus OH USA"},{"name":"The Institute for Behavioral Medicine Research, The Ohio State University Wexner Medical Center Columbus OH USA"},{"name":"Department of Obstetrics and Gynecology The Ohio State University Wexner Medical Center Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1009-9625","authenticated-orcid":false,"given":"Julian","family":"Koenig","sequence":"additional","affiliation":[{"name":"Section for Experimental Child and Adolescent Psychiatry, Department of Child and Adolescent Psychiatry, Centre for Psychosocial Medicine University of Heidelberg Heidelberg Germany"},{"name":"University Hospital of Child and Adolescent Psychiatry and Psychotherapy University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DeWayne P.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Psychological Science The University of California Irvine Irvine CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaston","family":"Kapuku","sequence":"additional","affiliation":[{"name":"Georgia Prevention Institute Georgia Health Sciences University Augusta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian F.","family":"Thayer","sequence":"additional","affiliation":[{"name":"Department of Psychological Science The University of California Irvine Irvine CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,11]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"1","volume-title":"Fetal origins of cardiovascular and lung disease","author":"Barker D. J.","year":"2000"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000335246.93495.92"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0000000000000820"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2832"},{"issue":"19","key":"e_1_2_9_6_1","first-page":"S0149","article-title":"At the forefront of psychoneuroimmunology in pregnancy: Implications for racial disparities in birth outcomes PART 1: Behavioral risks factors","volume":"30331","author":"Christian L. M.","year":"2019","journal-title":"Neuroscience & Biobehavioral Reviews"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0b013e31829bbc89"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.94.12.2132"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyg036"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/NNR.0b013e3181ac1599"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0033718"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0b013e31816f28de"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2007.03.022"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2004.10.020"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e318180bc80"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.28.1.31"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.131.5.662"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.111066"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.090308"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0000000000000133"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0031160"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0b013e31816f2709"},{"key":"e_1_2_9_23_1","first-page":"74","volume-title":"The Dynamics of aggression","author":"Hokanson J. E.","year":"1970"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0040236"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0047125"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0023053"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0046864"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-6494.1968.tb01481.x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.17.1_Suppl.I129"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(99)70135-9"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2010.05.003"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1159\/000119004"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0277-9536(90)90307-E"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.86.10.1370"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2005.03.006"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.9.1264"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2010.02.002"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000253507.56499.bb"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.113.005033"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199312000-00016"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1996.03530440070039"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.1990.tb02171.x"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-1451-9_2"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7176.2010.00269.x"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.5.1043"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-09488-5_47"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-006-0058-z"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.5812\/ijem.14098"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2015.96"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2005.08.008"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(00)01199-7"},{"key":"e_1_2_9_52_1","article-title":"A preliminary report on ethnic differences in baroreflex function\u2010unraveling the cardiovascular conundrum","author":"Williams D. P.","year":"2016","journal-title":"Psychosomatic Medicine"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.17.1_Suppl.I122"}],"container-title":["Psychophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/psyp.13699","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/psyp.13699","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/psyp.13699","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T10:49:48Z","timestamp":1693565388000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/psyp.13699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,11]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1111\/psyp.13699"],"URL":"https:\/\/doi.org\/10.1111\/psyp.13699","archive":["Portico"],"relation":{},"ISSN":["0048-5772","1469-8986"],"issn-type":[{"value":"0048-5772","type":"print"},{"value":"1469-8986","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,11]]},"assertion":[{"value":"2020-04-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13699"}}