{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T05:04:08Z","timestamp":1776056648943,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T00:00:00Z","timestamp":1604102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH112558"],"award-info":[{"award-number":["R01MH112558"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R21MH087748"],"award-info":[{"award-number":["R21MH087748"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychophysiology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Individuals with hoarding disorder (HD) typically perform worse than peers on neuropsychological tasks involving visual perception. Functional neuroimaging shows diffusely increased activity in the visual cortex, consistent with inefficient visual processing in HD. The temporal locus of these inefficiencies in HD is unknown. This study examined the temporal unfolding of visual event\u2010related brain potentials (ERPs) to help better define the neurophysiological mechanisms underlying visual dysfunction in HD. Thirty\u2010three individuals with HD and 35 healthy controls (HC) were assessed using a 64\u2010channel EEG during a modified flanker task. Permutation\u2010controlled analyses were conducted to detect group differences in visual evoked ERPs on a millisecond\u2010to\u2010millisecond basis. Bayesian ANCOVAs and linear regressions that included hoarding and age were conducted to identify the best\u2010fit model for the identified VEPs, compared to a null model that included depression and anxiety severity. Three temporal regions (175\u00a0ms, 270\u00a0ms, and 440\u00a0ms), showed differences in amplitude between HD and HC and were consistent with ERP components N1, P1\/N2, and a late negative slow wave (LNSW), respectively. After controlling for depression and anxiety, HD demonstrated an enhanced ERP amplitude at N1 and an attenuated amplitude in LNSW compared to HC but did not show differences at P1\/N2. For the N1 and LNSW, there was also a primary effect of the interaction between hoarding and age. This study indicates that altered visuocortical reactivity in HD first occurs at the level of visuocortical processing after 170\u00a0ms, indicating alterations of middle and later, but not early, processing in occipitotemporal visual cortex.<\/jats:p>","DOI":"10.1111\/psyp.13711","type":"journal-article","created":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T13:46:31Z","timestamp":1604151991000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Electrophysiological dynamics of visuocortical processing in hoarding disorder"],"prefix":"10.1111","volume":"58","author":[{"given":"Na","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Psychiatry Center for OCD, Anxiety, and Related Disorders College of Medicine University of Florida Gainesville FL USA"},{"name":"Department of Medical Psychology Nanjing Brain Hospital affiliated to Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6821-2603","authenticated-orcid":false,"given":"Jessica J.","family":"Zakrzewski","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Center for OCD, Anxiety, and Related Disorders College of Medicine University of Florida Gainesville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol A.","family":"Mathews","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Center for OCD, Anxiety, and Related Disorders College of Medicine University of Florida Gainesville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Keil","sequence":"additional","affiliation":[{"name":"Department of Psychology Center for the Study of Emotion &amp; Attention University of Florida Gainesville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4002129"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocrd.2018.11.001"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10862-018-09716-9"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.56.6.893"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15327752jpa6703_13"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1109\/78.554307"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.1993.tb02075.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2016.00168"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2016.11.006"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2015.02.025"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-019-1078-0"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2235214100"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.03.018"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03203267"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2003.07.006"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.20861"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10862-007-9068-7"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocrd.2014.12.006"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2012.02.006"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.3.781"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2016.07.007"},{"key":"e_1_2_8_23_1","unstructured":"JASP Team. 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