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The current study aimed to assess arterial stiffness via carotid\u2010femoral pulse wave velocity (cfPWV) in the acute and weight\u2010restored states of AN. The study also aimed to determine the association between psychological distress and cfPWV. The sample included 37 participants; 10 participants with AN, 17 who were weight\u2010restored (AN\u2010WR; minimum body mass index &gt;18.5 for at least 12\u00a0months) and 10 healthy controls (HCs). cfPWV via applanation tonometry was conducted to assess arterial stiffness. Psychological distress was assessed using the depression anxiety stress scale (DASS\u201021) and the state\u2010trait anxiety inventory (STAI). Between\u2010group comparisons were performed to determine differences between groups, a two\u2010stage hierarchical regression model was performed to determine the contribution of physiological and psychological variables on cfPWV and correlation analyses were also performed. Vascular stiffness was significantly increased in the AN and AN\u2010WR groups, relative to HCs. The total DASS score was the only significant predictor of cfPWV across the sample. There were positive associations between cfPWV and depression, anxiety and stress, as assessed by the DASS. Furthermore, cfPWV was positively associated with STAI trait anxiety. Arterial stiffness was increased in individuals in the acute and weight\u2010restored states of AN, demonstrating early signs of the development of arteriosclerotic cardiovascular disease. Increased arterial stiffness was associated with increased psychological distress, which may be a contributing mechanism to the increased cardiovascular risk in AN.<\/jats:p>","DOI":"10.1111\/psyp.13913","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T19:45:28Z","timestamp":1627501528000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Arterial stiffness in underweight and weight\u2010restored anorexia nervosa"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8551-0792","authenticated-orcid":false,"given":"Zoe M.","family":"Jenkins","sequence":"first","affiliation":[{"name":"Iverson Health Innovation Research Institute Swinburne University of Technology Melbourne Victoria Australia"},{"name":"Department of Mental Health St Vincent\u2019s Hospital Melbourne Fitzroy Victoria Australia"},{"name":"Department of Psychiatry University of 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