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Despite its apparent sedative and calming effects,\n                    <jats:italic>cannabis<\/jats:italic>\n                    and its main psychoactive constituent, \u2206\n                    <jats:sup>9<\/jats:sup>\n                    \u2010tetrahydrocannabinol (THC) can produce serious adverse effects including tachycardia and anxiety. These effects can be especially pronounced in women, who remain underrepresented in clinical cannabinoid research. The present study is one of the first to characterize the effects of single doses of oral THC on autonomic nervous system function in healthy adult women. Occasional female\n                    <jats:italic>cannabis<\/jats:italic>\n                    users participated in three laboratory sessions in which they received oral THC (7.5 and 15\u00a0mg) and placebo. Autonomic measures included heart rate (HR), blood pressure (BP), pre\u2010ejection period (PEP) a measure of cardiac sympathetic functioning, and high frequency heart rate variability (HF\u2010HRV) a measure of parasympathetic cardiac control. Autonomic responses were examined in relation to subjective drug effects. THC dose\u2010dependently increased HR, decreased HF\u2010HRV, and increased ratings of feeling a drug effect,\n                    <jats:italic>cannabis<\/jats:italic>\n                    \u2010like intoxication, and anxiety. Although the drug did not significantly affect BP or PEP, HR was negatively related to both PEP and HF\u2010HRV. HF\u2010HRV, the measure of parasympathetic activity, was significantly negatively related to subjective measures of\n                    <jats:italic>cannabis<\/jats:italic>\n                    intoxication (but not anxiety) at the 15\u00a0mg dose only. PEP was not significantly related to any subjective measure. These results extend our knowledge of the autonomic effects of THC in relation to subjective drug experience. This and future studies will help us to understand risk factors related to\n                    <jats:italic>cannabis<\/jats:italic>\n                    use.\n                  <\/jats:p>","DOI":"10.1111\/psyp.13955","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T07:27:47Z","timestamp":1634801267000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Acute effects of oral delta\u20109\u2010tetrahydrocannabinol (THC) on autonomic cardiac activity and their relation to subjective and anxiogenic effects"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6669-7259","authenticated-orcid":false,"given":"Elisa","family":"Pabon","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Neurosciences University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederica","family":"Rockwood","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg J.","family":"Norman","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harriet","family":"de Wit","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neurosciences University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.178.2.101"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1975.01760300086007"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197208032870501"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2015.08.004"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.2004.00156.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.2008.00652.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511546396.008"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.1997.tb02140.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00431259"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-200205000-00005"},{"key":"e_1_2_7_13_1","volume-title":"2019 National Survey on Drug Use and Health: Methodological summary and definitions","author":"Substance Abuse and Mental Health Services Administration (SAMHSA)","year":"2019"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0376-8716(85)90002-X"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2014.00080"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-019-00983-5"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.09.004"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0b013e31820c23fa"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300496"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.00776.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707465"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbu098"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2005.08.009"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.176.4037.934"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-019-05235-9"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1978.tb00832.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2013.03.003"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psc.2010.01.004"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1300\/J175v03n04_02"},{"key":"e_1_2_7_30_1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1300\/J175v03n04_01","article-title":"A phase I, open label, four\u2010way crossover study to compare the pharmacokinetic profiles of a single dose of 20 mg of a Cannabis Based Medicine Extract (CBME) Administered on 3 different areas of the buccal mucosa and to investigate the pharmacokinetics of CBME per Oral in Healthy Male and Female Volunteers (GWPK0112)","volume":"3","author":"Guy G. 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