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Among the studies meeting this purpose, we also evaluated studies investigating whether, and how, functional connectivity may influence the exercise\u2013cognition relationship. A systematic review was employed through several electronic databases (PsychInfo, PubMed, and Google Scholar) in accordance with PRISMA guidelines. The literature search identified 656 records, and a total of 12 studies met the inclusion criteria. Among these 12 studies, there were 4, 7, and 1 study, respectively, examining the relationship between exercise and frontal lobe connectivity, temporal lobe connectivity, and whole\u2010brain connectivity. Also, 7 studies examined the relationship between functional connectivity and cognitive performance across multiple brain regions as a function of exercise. Existing literature suggests that CRF, habitual physical activity, and varying intensities of acute exercise can strengthen functional connections among a wide variety of regions and subcortical structures of the human brain. These exercise\u2010induced functional connectivity changes within and between specific brain structures\/networks supporting cognitive processing may improve various domains of cognitive function. Given these complex associations, a thorough understanding of how functional connectivity plays a mediating role in the exercise\u2013cognition interaction is needed in future studies.<\/jats:p>","DOI":"10.1111\/psyp.14014","type":"journal-article","created":{"date-parts":[[2022,2,5]],"date-time":"2022-02-05T18:43:50Z","timestamp":1644086630000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Interrelationships between exercise, functional connectivity, and cognition among healthy adults: A\u00a0systematic review"],"prefix":"10.1111","volume":"59","author":[{"given":"Damien","family":"Moore","sequence":"first","affiliation":[{"name":"Exercise and Memory Laboratory, Department of Health, Exercise Science and Recreation Management The University of Mississippi  University Mississippi USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myungjin","family":"Jung","sequence":"additional","affiliation":[{"name":"Exercise and Memory Laboratory, Department of Health, Exercise Science and Recreation Management The University of Mississippi  University Mississippi USA"},{"name":"Health and Sport Analytics Laboratory, Department of Health, Exercise Science and Recreation Management The University of Mississippi  University Mississippi USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles H.","family":"Hillman","sequence":"additional","affiliation":[{"name":"Center for Cognitive &amp; Brain Health, Department of Psychology, Department of Physical Therapy, Movement &amp; Rehabilitation Sciences Northeastern University  Boston Massachusetts United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minsoo","family":"Kang","sequence":"additional","affiliation":[{"name":"Health and Sport Analytics Laboratory, Department of Health, Exercise Science and Recreation Management The University of Mississippi  University Mississippi USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7711-4741","authenticated-orcid":false,"given":"Paul\u00a0D.","family":"Loprinzi","sequence":"additional","affiliation":[{"name":"Exercise and Memory Laboratory, Department of Health, Exercise Science and Recreation Management The University of Mississippi  University Mississippi USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12360"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1162\/08989290051137521"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00426"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2013.189"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S135561771500106X"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep10964"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1510619112"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2007.9.2\/rbonelli"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2021.111493"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1440.011"},{"issue":"2","key":"e_1_2_8_12_1","first-page":"126","article-title":"Physical activity, exercise, and physical fitness: Definitions and distinctions for health\u2010related research","volume":"100","author":"Caspersen C. 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