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However, studies related to subthreshold depression's (SD) cognitive deficits and neuromodulation approaches for the treatment of SD are still rare. We adopted Beck's cognitive model of depression and tested the tDCS stimulation effects on attentional and memory deficits on SD. First, this was a single\u2010blinded, randomized, sham\u2010controlled clinical trial to determine a 13\u2010day tDCS modulation effect on 49 SD (27: Stimulation; 22: Sham) and 17 healthy controls. Second, the intervention effects of the consecutive and single\u2010session tDCS were compared. Furthermore, the attentional and memory biases were explored in SD. Anodal tDCS was administrated over left dorsolateral prefrontal cortex for 13 consecutive days. Attentional and memory bias were assessed through a modified Sternberg task and a dot\u2010probe task on the 1st, 2nd, and 15th day while their EEG was being recorded. After the 13\u2010day tDCS stimulation (not after single\u2010session stimulation), we found reduced memory bias (Stimulation vs. Sham, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.02, <jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u2009.09) and decreased mid\u2010frontal alpha power (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01, <jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u2009.13). In contrast, tDCS did not affect any attentional related behavioral or neural indexes (all <jats:italic>p<\/jats:italic>s\u2009&gt;\u2009.15). Finally, reduced depressive symptoms (e.g., BDI score) were found for both groups. The criteria of SD varied across studies; the efficacy of this protocol should be tested in elderly patients. Our study suggests memory bias of SD can be modulated by the multisession tDCS and alpha power could serve as a neural index for intervention.<\/jats:p>","DOI":"10.1111\/psyp.14148","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T15:31:32Z","timestamp":1657639892000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Using multisession tDCS stimulation as an early intervention on memory bias processing in subthreshold depression"],"prefix":"10.1111","volume":"60","author":[{"given":"Chialun","family":"Liu","sequence":"first","affiliation":[{"name":"Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, Division of Life Science and Medicine University of Science &amp; Technology of China  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlu","family":"Xie","sequence":"additional","affiliation":[{"name":"Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, Division of Life Science and Medicine University of Science &amp; 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Technology of China  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Wu","sequence":"additional","affiliation":[{"name":"Centre for Cognitive and Brain Sciences (CCBS) University of Macau (UM)  Macau China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niccolo'","family":"Pescetelli","sequence":"additional","affiliation":[{"name":"Hybrid Collective Intelligence Group Center for Humans and Machines, Max Planck Institute for Human Development  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7541-0130","authenticated-orcid":false,"given":"Xiaochu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Psychology, School of Humanities &amp; Social Science University of Science &amp; Technology of China  Hefei China"},{"name":"Department of Radiology, the First Affiliated Hospital of USTC, Hefei National Research Center for Physical Sciences at the Microscale and School of Life Science, Division of Life Science and Medicine University of Science &amp; 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