{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T08:41:24Z","timestamp":1782808884017,"version":"3.54.5"},"reference-count":70,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:00:00Z","timestamp":1699401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["F31 DA039644\u201001A1"],"award-info":[{"award-number":["F31 DA039644\u201001A1"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychophysiology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cannabis use disorder (CUD) is increasing in the United States, yet, specific neural mechanisms of CUD are not well understood. Disordered substance use is characterized by heightened drug cue incentive salience, which can be measured using the late positive potential (LPP), an event\u2010related potential (ERP) evoked by motivationally significant stimuli. The drug cue LPP is typically quantified by averaging the slow wave's scalp\u2010recorded amplitude across its entire time course, which may obscure distinct underlying factors with differential predictive validity; however, no study to date has examined this possibility. In a sample of 105 cannabis users, temporo\u2010spatial Principal Component Analysis was used to decompose cannabis cue modulation of the LPP into its underlying factors. Acute stress was also inducted to allow for identification of specific cannabis LPP factors sensitive to stress. Factor associations with CUD severity were also explored. Eight factors showed significantly increased amplitudes to cannabis images relative to neutral images. These factors spanned early (~372 ms), middle (~824 ms), and late (&gt;1000 ms) windows across frontal, central, and parietal\u2010occipital sites. CUD phenotype individual differences were primarily associated with frontal, middle\/late latency factor amplitudes. Acute stress effects were limited to one early central and one late frontal factor. Taken together, results suggest that the cannabis LPP can be decomposed into distinct, temporal\u2010spatial factors with differential responsivity to acute stress and CUD phenotype variability. Future individual difference studies examining drug cue modulation of the LPP should consider (1) frontalcentral poolings in addition to conventional central\u2010parietal sites, and (2) later LPP time windows.<\/jats:p>","DOI":"10.1111\/psyp.14471","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T12:19:20Z","timestamp":1699445960000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Decomposing the late positive potential to cannabis cues in regular cannabis users: A temporal\u2013spatial principal component analysis"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5007-1999","authenticated-orcid":false,"given":"Thomas J.","family":"Preston","sequence":"first","affiliation":[{"name":"Department of Psychological Sciences Auburn University  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse R.","family":"Cougle","sequence":"additional","affiliation":[{"name":"Department of Psychology Florida State University  Tallahassee Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman B.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Psychology Florida State University  Tallahassee Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Macatee","sequence":"additional","affiliation":[{"name":"Department of Psychological Sciences Auburn University  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2013.09.012"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033\u2010295X.111.1.33"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1037\/amp0000059"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/SAR.S109576"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/10550490903077705"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2009.221"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2010.08.015"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.yco.0000218592.00689.e5"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.11.1967"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/10253890.2021.1929164"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1550059413495533"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2017.07.008"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15327906mbr0102_10"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369\u20101600.2011.00417.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.07.048"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2009.12.009"},{"key":"e_1_2_6_18_1","first-page":"189","volume-title":"Event\u2010related potentials: A methods handbook","author":"Dien J."},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20304"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0926\u20106410(03)00188\u20105"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.56.8.588"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1037\/bul0000096"},{"key":"e_1_2_6_23_1","first-page":"248","volume-title":"Addictive behaviour: Cue exposure theory and practice","author":"Drummond D. 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