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While increasing evidence indicates a pivotal role of disgust in the development of contamination\u2010based obsessive\u2010compulsive disorder (C\u2010OCD), dysregulations in conditioned disgust acquisition and maintenance, in particular driven by higher\u2010order conceptual processes, have not been examined. Here, we address this gap by exposing individuals with high (HCC, <jats:italic>n<\/jats:italic>\u2009=\u200941) or low (LCC, <jats:italic>n<\/jats:italic>\u2009=\u200941) contamination concern to a conceptual\u2010level disgust conditioning and extinction paradigm. Conditioned stimuli (CS+) were images from one conceptual category partially reinforced by unconditioned disgust\u2010eliciting stimuli (US), while images from another category served as non\u2010reinforced conditioned stimuli (CS\u2212). Skin conductance responses (SCRs), US expectancy and CS valence ratings served as primary outcomes to quantify conditioned disgust responses. Relative to LCC, HCC individuals exhibited increased US expectancy and CS+ disgust experience, but comparable SCR levels following disgust acquisition. Despite a decrease in conditioned responses from the acquisition phase to the extinction phase, both groups did not fully extinguish the learned disgust. Importantly, the extinction resilience of acquired disgust was more pronounced in HCC individuals. Together, our findings suggest that individuals with high self\u2010reported contamination concern exhibit increased disgust acquisition and resistance to extinction. The findings provide preliminary evidence on how dysregulated disgust learning mechanism across semantically related concepts may contribute to C\u2010OCD.<\/jats:p>","DOI":"10.1111\/psyp.14637","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T14:56:50Z","timestamp":1719413810000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Conceptual\u2010level disgust conditioning in contamination\u2010based obsessive\u2010compulsive disorder"],"prefix":"10.1111","volume":"61","author":[{"given":"Jinxia","family":"Wang","sequence":"first","affiliation":[{"name":"Institute for Brain and Psychological Sciences Sichuan Normal University  Chengdu China"},{"name":"Department of Psychology, Centre for Interdisciplinary Brain Research University of Jyvaskyla  Jyvaskyla Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Becker","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Brain and Cognitive Sciences, Department of Psychology The University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhen","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Psychology South China Normal University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianchao","family":"Ming","sequence":"additional","affiliation":[{"name":"School of Psychology South China Normal University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8874-923X","authenticated-orcid":false,"given":"Yi","family":"Lei","sequence":"additional","affiliation":[{"name":"Institute for Brain and Psychological Sciences Sichuan Normal University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Wikgren","sequence":"additional","affiliation":[{"name":"Department of Psychology, Centre for Interdisciplinary Brain Research University of Jyvaskyla  Jyvaskyla Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,26]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2006.03.001"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2014.01.004"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/10615806.2010.506953"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/2167702619863769"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2017.03.009"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocrd.2014.11.001"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0013164402062004005"},{"key":"e_1_2_13_9_1","doi-asserted-by":"crossref","unstructured":"Beck A. 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