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Moreover, the few previous studies on this topic have mostly employed univariate analyses, with limited and unbalanced samples, leading to inconsistent results. To overcome these limitations, and to characterize the neural underpinnings of SAP, this study aims to develop a classification model of individuals with SAP based on gray matter features, by using a machine learning method known as the binary support vector machine. Moreover, the contribution of specific structural macro\u2010networks, such as the default mode, the salience, the executive, and the affective networks, in separating phobic subjects from controls was assessed. Thirty\u2010two subjects with SAP and 90 matched healthy controls were tested to this aim. At a whole\u2010brain level, we found a significant predictive model including brain structures related to emotional regulation, cognitive control, and sensory integration, such as the cerebellum, the temporal pole, the frontal cortex, temporal lobes, the amygdala and the thalamus. Instead, when considering macro\u2010networks analysis, we found the Default, the Affective, and partially the Central Executive and the Sensorimotor networks, to significantly outperform the other networks in classifying SAP individuals. In conclusion, this study expands knowledge about the neural basis of SAP, proposing new research directions and potential diagnostic strategies.<\/jats:p>","DOI":"10.1111\/psyp.14716","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:11:31Z","timestamp":1730160691000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The phobic brain: Morphometric features correctly classify individuals with small animal phobia"],"prefix":"10.1111","volume":"62","author":[{"given":"Alessandro","family":"Scarano","sequence":"first","affiliation":[{"name":"Department of Psychology and Cognitive Science University of Trento  Trento Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ascensi\u00f3n","family":"Fumero","sequence":"additional","affiliation":[{"name":"Departamento de Psicolog\u00eda Cl\u00ednica, Psicobiolog\u00eda y Metodolog\u00eda, Facultad de Psicolog\u00eda 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