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Previous studies found both the hippocampus (HIP) and orbitofrontal cortex (OFC) are involved in this process. However, it is still unclear how the interaction between them responds to the inference\u2010based decision. We recruited healthy adult subjects to perform an inference task during the functional magnetic resonance imaging (fMRI) scanning. Subjects were required to use their learned knowledge of hierarchical relationships to infer for novel decisions. We found that the HIP and OFC represented the cognitive map in social space. Beta\u2010series correlation analysis revealed that inference\u2010based decisions were accompanied by increased HIP\u2010OFC connectivity. Moreover, the HIP\u2010seeded correlation map included widespread regions in the visual areas, prefrontal cortex, medial temporal lobe, and temporoparietal cortex. The OFC\u2010seeded correlation map contained visual areas, sensorimotor areas, prefrontal cortex, medial temporal lobe, temporoparietal cortex, insula, and putamen. These results suggested that the interactions between HIP and OFC may support inference\u2010based decisions.<\/jats:p>","DOI":"10.1111\/psyp.70180","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T10:00:16Z","timestamp":1762941616000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Functional Connectivity Between Human Hippocampus and Orbitofrontal Cortex Supports Inference\u2010Based Decision Making"],"prefix":"10.1111","volume":"62","author":[{"given":"Jinhui","family":"Li","sequence":"first","affiliation":[{"name":"Department of Public Health and Preventive Medicine, Division of Medical Psychology and Behavior Science, School of Medicine Jinan University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiajun","family":"Liao","sequence":"additional","affiliation":[{"name":"School of Psychology Shenzhen University  Shenzhen 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