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Pain perception is tied to increased arousal and heart rate. Heart rate perception is, in turn, closely related to interoceptive signals processing, for example, pain and autonomic regulation. However, no studies so far have systematically examined the generalizing versus specific effects of placebo analgesia in transferring from pain to the interoception of cardiac signals. In this preregistered, exploratory study, we aim to investigate whether the placebo analgesia effect on pain may generalize to the perception of one's own heartbeat. We recruited 88 healthy participants (47 female, 41 male), of which half (23 female, 21 male) underwent a deceptive placebo analgesia induction. Using the Heartbeat Counting Task and the MAIA questionnaire, we derived three interoceptive dimensions: interoceptive accuracy, sensibility (at both task\u2010related and trait levels), and awareness. Despite a robust placebo analgesia effect, no difference between the placebo and the control group was found in any of the interoceptive dimensions. These findings were supported by post hoc Bayesian analyses, which indicated moderate evidence for this absence of a group difference. Our findings thus do not indicate a generalization of the placebo analgesia effect from pain to cardiac interoceptive awareness. Studies such as the present one are important to better understand the perception of different bodily systems and their connection in humans.<\/jats:p>","DOI":"10.1111\/psyp.70391","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T14:49:51Z","timestamp":1788014991000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Placebo Analgesia Does Not Generalize From Pain to Interoceptive Abilities: A Preregistered Exploratory Study"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1331-6683","authenticated-orcid":false,"given":"Helena","family":"Hartmann","sequence":"first","affiliation":[{"name":"Social, Cognitive and Affective Neuroscience Unit, Department of Cognition, Emotion, and Methods in Psychology, Faculty of Psychology University of Vienna  Vienna Austria"},{"name":"Department for Neurology and Center for Translational Neuro\u2010 and Behavioral Sciences (C\u2010TNBS) University Hospital Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Proposito","sequence":"additional","affiliation":[{"name":"Social, Cognitive and Affective Neuroscience Unit, Department of Cognition, Emotion, and Methods in Psychology, Faculty of Psychology University of Vienna  Vienna Austria"},{"name":"Donders Institute for Brain, Cognition and Behaviour Radboud University Medical Center  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Riva","sequence":"additional","affiliation":[{"name":"Social, Cognitive and Affective Neuroscience Unit, Department of Cognition, Emotion, and Methods in Psychology, Faculty of Psychology University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5422-0653","authenticated-orcid":false,"given":"Claus","family":"Lamm","sequence":"additional","affiliation":[{"name":"Social, Cognitive and Affective Neuroscience Unit, Department of Cognition, Emotion, and Methods in Psychology, Faculty of Psychology University of Vienna  Vienna Austria"},{"name":"Vienna Cognitive Science Hub University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2020.107870"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.15191.2"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/caff.2017.0011"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13854"},{"issue":"1","key":"e_1_2_10_6_1","first-page":"23","article-title":"Validierung Der Deutschen Version der 20\u2010Item Toronto\u2010Alexithymie\u2010Skala bei Normalpersonen und Psychiatrischen Patienten","volume":"46","author":"Bach M.","year":"1996","journal-title":"PPmP, Psychotherapie, Psychosomatik, Medizinische Psychologie"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001981"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002820"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S152012"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhv076"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21503"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2016.00743"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actpsy.2020.103215"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.04.005"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.371"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2020.107869"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn894"},{"key":"e_1_2_10_18_1","first-page":"272","volume-title":"Handbook of Emotion","author":"Craig A. 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