{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:56:42Z","timestamp":1791392202260,"version":"4.3.3"},"reference-count":69,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["PP00P3_176985"],"award-info":[{"award-number":["PP00P3_176985"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychophysiology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Interoception, the processing of internal bodily signals, has been linked to the pathophysiology of Functional Neurological Disorder (FND), along with the theoretical concept of altered predictive coding (PC). FND symptoms such as sensory\u2010motor dysfunction may arise from disrupted integration of sensory input and predictions. However, PC in the modality of interoception has not yet been investigated in FND. Using a PC paradigm, the cardio\u2010audio synchronization task measured electrophysiological responses to the heartbeat during omitted sounds that were temporally locked to the heartbeat (synchronous condition) or not (asynchronous control condition). Patients with mixed FND symptoms (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u200936) were compared to sex\u2010 and age\u2010matched healthy controls (HC:\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u200942) by contrasting synchronous and asynchronous heartbeat\u2010evoked potentials during omissions using cluster\u2010based permutation statistics. We further tested associations with self\u2010reported interoceptive variables and assessed whole\u2010scalp main and interaction effects in global field power (GFP) and topography. Patients with FND showed no cluster\u2010level differences between conditions, whereas we identified a central cluster difference in HCs. The interoceptive\u2010specific contrast (synch\u2010asynch difference waves) differed between groups and correlated with interoceptive self\u2010report but only when tested across groups (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u2009\u22120.33,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.012). In this paradigm, group\u2010by\u2010condition interactions in topography identified the insula as the most probable source of differences. These interactions occurred before those identified in GFP analyses, suggesting that differential networks emerge first, followed by changes in overall activity strength. These results indicate that patients with FND use different neural mechanisms for interoceptive PC (i.e., precision\u2010weighted prediction errors in interoception\u2010guided predictions) than HCs. Patients with FND showed no difference in interoceptive PC, suggesting a dysfunctional interoceptive system. Together, these findings suggest that interoceptive\u2010cued regularity processing in FND is characterized by altered early network recruitment, followed by differences in overall signal strength, potentially reflecting a disrupted progression of\n                    <jats:italic>interoceptive PC<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/psyp.70417","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:21:34Z","timestamp":1791390094000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Altered Interoceptive Predictive Coding in Functional Neurological Disorders"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4198-4921","authenticated-orcid":false,"given":"Natascha","family":"Stoffel","sequence":"first","affiliation":[{"name":"Department of Neurology, Faculty of Science and Medicine University of Fribourg  Fribourg Switzerland"},{"name":"Graduate School for Health Sciences (GHS) University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u00ebl","family":"Mouthon","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Science and Medicine University of Fribourg  Fribourg Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1323-2803","authenticated-orcid":false,"given":"Andria","family":"Pelentritou","sequence":"additional","affiliation":[{"name":"Brain\u2010Body and Consciousness Laboratory, Department of Clinical Neuroscience Lausanne University Hospital, University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"von der Weid","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Science and Medicine University of Fribourg  Fribourg Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9755-3298","authenticated-orcid":false,"given":"Cristina","family":"Concetti","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Science and Medicine University of Fribourg  Fribourg Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8792-7885","authenticated-orcid":false,"given":"Marzia","family":"De Lucia","sequence":"additional","affiliation":[{"name":"Brain\u2010Body and Consciousness Laboratory, Department of Clinical Neuroscience Lausanne University Hospital, University of Lausanne  Lausanne Switzerland"},{"name":"Center for Biomedical Imaging  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7877-6760","authenticated-orcid":false,"given":"Selma","family":"Aybek","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Science and Medicine University of Fribourg  Fribourg Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2016.0003"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0956797613498"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.o64"},{"key":"e_1_2_11_5_1","volume-title":"Beck Depression Inventory\u2013II","author":"Beck A. 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