{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:37:16Z","timestamp":1759937836050},"reference-count":40,"publisher":"Wiley","issue":"s6","license":[{"start":{"date-parts":[[2012,12,24]],"date-time":"2012-12-24T00:00:00Z","timestamp":1356307200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Contents<\/jats:title><jats:p>Pre\u2010eclampsia affects 2\u20138% of pregnant women worldwide and is the third leading cause of maternal mortality in the <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>nited <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tates, accounting for 20% of maternal deaths, for which the only known cure is delivery of the placenta. It is known that pre\u2010eclampsia results from defects within the trophoblast invasion of the endometrium and myometrium. At a morphological level within the pre\u2010eclamptic human placenta, trophoblast invasion is shallow, and this results in hypoperfusion, which is a life\u2010threatening condition for both the mother and the foetus. Pre\u2010eclampsia has been intensively investigated for over 50\u00a0years, and yet the causes are largely unknown. Despite a large body of data, it is still unknown exactly which mechanisms regulate trophoblast invasion. An effective animal model may be crucial to understanding the underlying causes of pre\u2010eclampsia. A canine model is a proposed improvement on the current efforts to investigate disorders of shallow trophoblast invasion throughout gestation and to improve understanding of the factors that regulate trophoblast invasion. The objectives of this research were to elucidate and compare cellular and molecular similarities between normal canine trophoblasts with those from recently published reports on pre\u2010eclampsia in women.<\/jats:p>","DOI":"10.1111\/rda.12037","type":"journal-article","created":{"date-parts":[[2012,12,24]],"date-time":"2012-12-24T06:03:59Z","timestamp":1356329039000},"page":"186-189","source":"Crossref","is-referenced-by-count":7,"title":["Who Let the Dogs In: A Canine Trophoblast Invasion Model for Pre\u2010eclampsia"],"prefix":"10.1111","volume":"47","author":[{"given":"M","family":"Kutzler","sequence":"first","affiliation":[{"name":"Department of Animal and Rangeland Sciences Theriogenology Laboratory Oregon State University Corvallis OR USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Sahlfeld","sequence":"additional","affiliation":[{"name":"Department of Animal and Rangeland Sciences Theriogenology Laboratory Oregon State University Corvallis OR 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