{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:55:45Z","timestamp":1784130945107,"version":"3.55.0"},"reference-count":10,"publisher":"Wiley","issue":"s6","license":[{"start":{"date-parts":[[2012,12,24]],"date-time":"2012-12-24T00:00:00Z","timestamp":1356307200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:sec><jats:title>Contents<\/jats:title><jats:p>Stray dogs are a significant problem in large cities. Contraception is an important and useful solution to control the growing population of these dogs. Early\u2010age neutering is an effective technique for canine population control; however, surgical neutering may not be possible in various situations. <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>n<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>\u2010agonist implantation has been successful for long\u2010term reversible contraception in dogs. The efficacy of <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>n<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>\u2010agonist implantation on long\u2010term suppression of reproductive performance was observed in male dogs. Eleven 4\u2010month\u2010old dogs were implanted with 4.7, 9.4\u00a0mg deslorelin or placebo. Sexual behaviour and testicular size were monitored every 2\u00a0months. Ejaculates were collected and evaluated at 8, 12, 15, 18, 24, 30, 32, 34 and 36\u00a0months of age. Dogs implanted with placebo were found to be healthy and in normal reproductive status. Most dogs (3\/4) implanted with 4.7\u00a0mg deslorelin showed male sexual behaviour at age of 34\u00a0months old. From this group, two dogs had normal semen quality, while semen could not be collected from the other dog, and after castration, no sperm were obtained following epididymal flushing. One dog implanted 4.7\u00a0mg deslorelin and four dogs implanted with 9.4\u00a0mg deslorelin remained in the non\u2010pubertal reproductive status at 30\u201334\u00a0months. The delay to puberty was longer in dogs implanted with higher dose of <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>n<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content> agonist. Implantation of pre\u2010pubertal dogs with high doses of <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>n<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content> agonist will delay the onset of puberty and may be an effective strategy to reduce the number of unwanted breedings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/rda.12066","type":"journal-article","created":{"date-parts":[[2012,12,24]],"date-time":"2012-12-24T06:03:59Z","timestamp":1356329039000},"page":"400-402","source":"Crossref","is-referenced-by-count":20,"title":["Delay of Puberty and Reproductive Performance in Male Dogs Following the Implantation of 4.7 and 9.4\u00a0mg <scp>G<\/scp>n<scp>RH<\/scp>\u2010Agonist Deslorelin at an Early Pre\u2010pubertal Age"],"prefix":"10.1111","volume":"47","author":[{"given":"S","family":"Sirivaidyapong","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Gynaecology and Reproduction Faculty of Veterinary Science Small Animal Teaching Hospital Chulalongkorn University Bangkok Thailand"},{"name":"Innovation Center for Obstetrics, Fertility and Reproductive Disorders Faculty of Veterinary Science Small Animal Teaching Hospital Chulalongkorn University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NS","family":"Mehl","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynaecology and Reproduction Faculty of Veterinary Science Small Animal Teaching Hospital Chulalongkorn University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TE","family":"Trigg","sequence":"additional","affiliation":[{"name":"PT Consulting Pty Limited Balmain NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1591(96)01133-1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2001.218.217"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2010.11.005"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2005.05.023"},{"key":"e_1_2_7_6_1","first-page":"223","article-title":"Early\u2010age neutering of dogs and cats in the United States (a review)","volume":"57","author":"Olson PN","year":"2001","journal-title":"J Reprod Fertil Suppl"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2006.01.032"},{"key":"e_1_2_7_8_1","unstructured":"SirivaidyapongS 2002:Motility and Viability of Canine Epididymal sperm Collected by Different Methods. (Proc). The 3rd EVSSAR Congress on Reproduction in Companion Exotic and Laboratory Animals. Liege Belgium. May: 170."},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0093-691X(99)00274-5"},{"key":"e_1_2_7_10_1","first-page":"1037","volume-title":"Kirk's Current Veterinary Therapy XII Small Animal Practice","author":"Stubbs WP","year":"1995"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2006.02.037"}],"container-title":["Reproduction in Domestic Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Frda.12066","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/rda.12066","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T23:48:08Z","timestamp":1694648888000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/rda.12066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":10,"journal-issue":{"issue":"s6","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1111\/rda.12066"],"URL":"https:\/\/doi.org\/10.1111\/rda.12066","archive":["Portico"],"relation":{},"ISSN":["0936-6768","1439-0531"],"issn-type":[{"value":"0936-6768","type":"print"},{"value":"1439-0531","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}