{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:08:20Z","timestamp":1790424500549,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"s6","license":[{"start":{"date-parts":[[2012,12,24]],"date-time":"2012-12-24T00:00:00Z","timestamp":1356307200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Contents<\/jats:title><jats:p>Among the modifications that occur during the neonatal period, pulmonary development is the most critical. The neonate's lungs must be able to perform adequate gas exchange, which was previously accomplished by the placenta. Neonatal respiratory distress syndrome is defined as insufficient surfactant production or pulmonary structural immaturity and is specifically relevant to preterm newborns. Prenatal maternal betamethasone treatment of bitches at 55\u00a0days of gestation leads to structural changes in the neonatal lung parenchyma and consequently an improvement in the preterm neonatal respiratory condition, but not to an increase in pulmonary surfactant production. Parturition represents an important challenge to neonatal adaptation, as the uterine and abdominal contractions during labour provoke intermittent hypoxia. Immediately after birth, puppies present venous mixed acidosis (low blood p<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content> and high dioxide carbon saturation) and low but satisfactory <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>pgar scores. Thus, the combination of physiological hypoxia during birth and the initial effort of filling the pulmonary alveoli with oxygen results in anaerobiosis. As a neonatal adaptation follow\u2010up, the Apgar analysis indicates a tachypnoea response after 1\u00a0h of life, which leads to a shift in the blood acid\u2013base status to metabolic acidosis. One hour is sufficient for canine neonates to achieve an ideal <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>pgar score; however, a haemogasometric imbalance persists. Dystocia promotes a long\u2010lasting bradycardia effect, slows down <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>pgar score progression and aggravates metabolic acidosis and stress. The latest data reinforce the need to accurately intervene during canine parturition and offer adequate medical treatment to puppies that underwent a pathological labour.<\/jats:p>","DOI":"10.1111\/rda.12078","type":"journal-article","created":{"date-parts":[[2012,12,24]],"date-time":"2012-12-24T06:03:59Z","timestamp":1356329039000},"page":"177-181","source":"Crossref","is-referenced-by-count":25,"title":["Prenatal and Neonatal Adaptations with a Focus on the Respiratory System"],"prefix":"10.1111","volume":"47","author":[{"given":"CI","family":"Vannucchi","sequence":"first","affiliation":[{"name":"Department of Animal Reproduction University of S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LCG","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Animal Reproduction University of S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CF","family":"L\u00facio","sequence":"additional","affiliation":[{"name":"Department of Animal Reproduction University of S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FM","family":"Regazzi","sequence":"additional","affiliation":[{"name":"Department of Animal Reproduction University of S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GAL","family":"Veiga","sequence":"additional","affiliation":[{"name":"Department of Animal Reproduction University of S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DS","family":"Angrimani","sequence":"additional","affiliation":[{"name":"Department of Animal Reproduction University of S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70316-9"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90210-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1092"},{"key":"e_1_2_8_5_1","first-page":"36","article-title":"Aspectos cardiorrespirat\u00f3rios e \u00e1cidos\u2010b\u00e1sicos do per\u00edodo de transi\u00e7\u00e3o fetal\u2010neonatal em c\u00e3es","volume":"57","author":"Crissiuma AL","year":"2005","journal-title":"Cl\u00ednica Veterin\u00e1ria"},{"key":"e_1_2_8_6_1","first-page":"429","article-title":"Sampling and storage of blood for pH and blood gas analysis","volume":"170","author":"Haskins SC","year":"1977","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_8_7_1","first-page":"987","article-title":"Respiratory distress in the newborn","volume":"76","author":"Hermansen CL","year":"2007","journal-title":"Am Fam Physician"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2527\/1996.7492067x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1995.tb03290.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0531.2009.01428.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1999.tb01025.x"},{"key":"e_1_2_8_12_1","first-page":"165","volume-title":"McDonald's Veterinary Endocrinology and Reproduction","author":"Martin PA","year":"2003"},{"key":"e_1_2_8_13_1","first-page":"63","volume-title":"Dist\u00farbios Respirat\u00f3rios No Per\u00edodo Neonatal","author":"Miyoshi MH","year":"1998"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(03)00825-1"},{"key":"e_1_2_8_15_1","first-page":"189","volume-title":"Arthur's Veterinary Reproduction and Obstetrics","author":"Noakes DE","year":"2001"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-1549"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-72032004000800010"},{"key":"e_1_2_8_18_1","first-page":"12","article-title":"Surfactante pulmonar: composi\u00e7\u00e3o, fun\u00e7\u00e3o e metabolismo","volume":"36","author":"Rebello CM","year":"2000","journal-title":"Pediatria Moderna"},{"key":"e_1_2_8_19_1","unstructured":"RegazziFM 2011:Lung morphometric and function changes in canine neonates after prenatal corticoterapy. 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