{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:14:53Z","timestamp":1761743693022},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,10,4]],"date-time":"2012-10-04T00:00:00Z","timestamp":1349308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Contents<\/jats:title><jats:p>Plasmatic concentrations of von<jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>illebrand<jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>actor (v<jats:styled-content style=\"fixed-case\">WF<\/jats:styled-content>) increase during pregnancy in humans and dogs; however the mechanism of such increase is still not well defined. The aims of this study were: (i) to evaluate changes in v<jats:styled-content style=\"fixed-case\">WF<\/jats:styled-content>concentration during pregnancy and during the subsequent oestrous cycle in bitches affected and unaffected by von<jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>illebrand<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>isease (v<jats:styled-content style=\"fixed-case\">WD<\/jats:styled-content>); (ii) to correlate the<jats:styled-content style=\"fixed-case\">vWF<\/jats:styled-content>levels and cortisol levels in both groups. Seven v<jats:styled-content style=\"fixed-case\">WD<\/jats:styled-content>affected (<jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>) and nine unaffected (<jats:styled-content style=\"fixed-case\">GII<\/jats:styled-content>) bitches were used. The animals were assessed during pregnancy, parturition, lactation and non\u2010gestational oestrous cycle in 11 moments (Pregnancy 1, Pregnancy 2, Parturition, Lactation 1, Lactation 2, Lactation 3, Anestrus, Proestrus, Oestrus, Diestrus 1, and Diestrus 2). The following tests were performed; measurement of von<jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>illebrand factor antigen (v<jats:styled-content style=\"fixed-case\">WF<\/jats:styled-content>:<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>g), albumin and cortisol. In both groups, v<jats:styled-content style=\"fixed-case\">WF<\/jats:styled-content>concentration remained stable during the non\u2010gestational oestrous cycle, but increased during pregnancy, with the highest value observed at parturition. Increases of 70% and 124% in v<jats:styled-content style=\"fixed-case\">WF<\/jats:styled-content>were seen in<jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">GII<\/jats:styled-content>, respectively, compared to anestrus. No correlation was found between v<jats:styled-content style=\"fixed-case\">WF<\/jats:styled-content>and cortisol. Values of v<jats:styled-content style=\"fixed-case\">WF<\/jats:styled-content>:<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>g changed during pregnancy, with a peak at parturition, both in v<jats:styled-content style=\"fixed-case\">WD<\/jats:styled-content>affected and unaffected animals. Values of v<jats:styled-content style=\"fixed-case\">WF<\/jats:styled-content>were not altered in the different phases of the oestrous cycle following pregnancy in both groups. Evaluation of v<jats:styled-content style=\"fixed-case\">WF<\/jats:styled-content>during pregnancy can cause false negative results for v<jats:styled-content style=\"fixed-case\">WD<\/jats:styled-content>, but assessment can be performed at any point in the oestrous cycle of non\u2010pregnant bitches.<\/jats:p>","DOI":"10.1111\/rda.12089","type":"journal-article","created":{"date-parts":[[2012,10,4]],"date-time":"2012-10-04T12:02:42Z","timestamp":1349352162000},"page":"416-422","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of von<scp>W<\/scp>illebrand Factor During Pregnancy, Lactation and Oestrous Cycle in Bitches Affected and Unaffected by von<scp>W<\/scp>illebrand Disease"],"prefix":"10.1111","volume":"48","author":[{"given":"CRS","family":"Mattoso","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine and Animal Science S\u00e3o Paulo State University Botucatu S\u00e3o Paulo 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