{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:21:52Z","timestamp":1761740512791},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,10,12]],"date-time":"2012-10-12T00:00:00Z","timestamp":1350000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Contents<\/jats:title><jats:p>Here is reported a disorder of sex development found in the <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ortuguese <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>usitano horse breed. The complex genital phenotype included mammary glands, abdominal testes without epididymis, connected through oviducts to pelvic hypoplastic uterine horns and fused vulvar <jats:italic>labia majora<\/jats:italic> from which protruded ventrally a penis\u2010like structure. This structure was presented in a reversed position, the urethral opening placed dorsally in the glans. However, it was functional both for micturition and erection. The horse exhibited female micturition posture and aggressive male\u2010like behaviour, including flehmen, mounting, thrusting and flagging of the tail. Plasma testosterone concentrations were below detection limits and the genetic evaluation revealed a 64, <jats:styled-content style=\"fixed-case\">XX<\/jats:styled-content>,<jats:italic> <jats:styled-content style=\"fixed-case\">SRY<\/jats:styled-content><\/jats:italic>\u2010negative karyotype. Surgery consisted in the removal of abdominal gonads followed by amputation of the penis and repositioning of the urethra. This case of reversion between the chromosomal and gonadal sex, associated with mixed anatomical and behavioural phenotype, illustrates that development of the testes may occur in the absence of the <jats:styled-content style=\"fixed-case\">SRY<\/jats:styled-content> gene and that other genetic and cellular pathways leading to gonad differentiation should be investigated.<\/jats:p>","DOI":"10.1111\/rda.12094","type":"journal-article","created":{"date-parts":[[2012,10,12]],"date-time":"2012-10-12T08:26:21Z","timestamp":1350030381000},"source":"Crossref","is-referenced-by-count":2,"title":["64, <scp>XX<\/scp>,<scp> SRY<\/scp>\u2010negative, Testicular <scp>DSD<\/scp> Syndrome in a <scp>L<\/scp>usitano Horse"],"prefix":"10.1111","volume":"48","author":[{"given":"A","family":"Torres","sequence":"first","affiliation":[{"name":"Reproduction and Obstetrics CIISA Faculty of Veterinary Medicine UTL Lisbon 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