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The study was performed on a commercial<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>olstein\u2010<jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>riesian dairy herd in northeastern Spain and the final data included those recorded in 53 non\u2010aborting and 19 aborting animals. Blood samples were collected immediately before pregnancy diagnosis (on Days 40, 90, 120, 150, 180 and 210 post\u2010insemination) in non\u2010aborting cows or until the time of abortion detection in aborting cows. General lineal models (GLM) repeated measures<jats:sc>anova<\/jats:sc>revealed the different behaviour of<jats:styled-content style=\"fixed-case\">PAG<\/jats:styled-content>\u20101 and<jats:styled-content style=\"fixed-case\">PAG<\/jats:styled-content>\u20102, and significant effects of<jats:italic><jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>eospora<\/jats:italic>seropositivity, cool season and twin pregnancy on plasma<jats:styled-content style=\"fixed-case\">PAG<\/jats:styled-content>\u20102 concentrations throughout gestation (between\u2010subject effects). In addition, based on the odds ratios, the likelihood of abortion increased in<jats:italic><jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>eospora<\/jats:italic>\u2010seropositive cows (by a factor of 7.0) compared to seronegative animals and decreased in cows with a high plasma<jats:styled-content style=\"fixed-case\">PAG<\/jats:styled-content>\u20102 concentration (&gt;4.5\u00a0ng\/ml) on Day 120 of pregnancy (by a factor of 0.24), compared to the remaining cows. In conclusion, there is a relationship between plasma<jats:styled-content style=\"fixed-case\">PAG<\/jats:styled-content>\u20102 concentrations and the risk of abortion in<jats:italic><jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>eospora<\/jats:italic>\u2010infected dairy cows. Thus, plasma<jats:styled-content style=\"fixed-case\">PAG<\/jats:styled-content>concentrations measured using anti\u2010bo<jats:styled-content style=\"fixed-case\">PAG<\/jats:styled-content>\u20102 antiserum on<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ay 120 of gestation could serve as an indicator of the abortion risk in<jats:italic><jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>.\u00a0caninum<\/jats:italic>infected animals; values &lt;4.5\u00a0ng\/ml indicating a high risk of abortion in chronically infected animals.<\/jats:p>","DOI":"10.1111\/rda.12134","type":"journal-article","created":{"date-parts":[[2012,12,11]],"date-time":"2012-12-11T21:36:21Z","timestamp":1355261781000},"page":"613-618","source":"Crossref","is-referenced-by-count":19,"title":["Plasma Concentrations of Pregnancy\u2010Associated Glycoproteins Measured Using Anti\u2010Bovine PAG\u20102 Antibodies on Day 120 of Gestation Predict Abortion in Dairy Cows Naturally Infected with<i><scp>N<\/scp>eospora caninum<\/i>"],"prefix":"10.1111","volume":"48","author":[{"given":"I","family":"Garc\u00eda\u2010Ispierto","sequence":"first","affiliation":[{"name":"Department of Animal Production University of Lleida Lleida Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Almer\u00eda","sequence":"additional","affiliation":[{"name":"Centre de Recerca en Sanitat Animal (CReSA) UAB\u2010IRTA Bellaterra Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Serrano","sequence":"additional","affiliation":[{"name":"Department of Animal Production University of Lleida Lleida Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NM","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Physiology of Reproduction Faculty of Veterinary Medicine University of Li\u00e8ge Li\u00e8ge Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JF","family":"Beckers","sequence":"additional","affiliation":[{"name":"Physiology of Reproduction Faculty of Veterinary Medicine University of Li\u00e8ge Li\u00e8ge Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"L\u00f3pez\u2010Gatius","sequence":"additional","affiliation":[{"name":"Department of Animal Production University of Lleida Lleida Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(02)00162-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4320(00)00117-2"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0531.2006.00804.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0093-691X(88)90046-5"},{"key":"e_1_2_8_6_1","first-page":"355","article-title":"Molecules of the family of aspartic proteinases in the placenta of ruminants: hormones or proteins?","volume":"149","author":"Beckers JF","year":"1994","journal-title":"Bull Mem Acad R Med Belg"},{"key":"e_1_2_8_7_1","unstructured":"BellaA SousaNM Lopez\u2010GatiusF Garcia\u2010IspiertoI SchoofsL ChahibaN BeckersJF2011:Development of a new radioimmunoassay using antiserum against pregnancy\u2010associated glycoprotein ii: concentrations in Holstein dairy cattle. 6th European Congress of Bovine Health and Management (ECBHM) 7\u20139 September p 63. 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