{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:15:15Z","timestamp":1782886515726,"version":"3.54.5"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Contents<\/jats:title><jats:p>This study evaluated the effects of follicular phase administration of <jats:styled-content style=\"fixed-case\">TAK<\/jats:styled-content>\u2010683, an investigational metastin\/kisspeptin analog, on follicular growth, ovulation, luteal function and reproductive hormones in goats. After confirmation of ovulation by transrectal ultrasonography (<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ay 0), <jats:styled-content style=\"fixed-case\">PGF<\/jats:styled-content><jats:sub>2<jats:italic>\u03b1<\/jats:italic><\/jats:sub> (2\u00a0mg\/head of dinoprost) was administered intramuscularly on <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ay 10 to induce luteal regression. At 12\u00a0h after <jats:styled-content style=\"fixed-case\">PGF<\/jats:styled-content><jats:sub>2<jats:italic>\u03b1<\/jats:italic><\/jats:sub> administration, intravenous administration of vehicle or 35\u00a0nmol (50\u00a0\u03bcg)\/head of <jats:styled-content style=\"fixed-case\">TAK<\/jats:styled-content>\u2010683 was performed in control (n\u00a0=\u00a04) and treatment (n\u00a0=\u00a04) groups, respectively. Blood samples were collected at 6\u2010h intervals for 96\u00a0h and then daily until the detection of subsequent ovulation (second ovulation). After the second ovulation, ultrasound examinations and blood sampling were performed every other day or daily until the subsequent ovulation (third ovulation). Mean concentrations of <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content> in the treatment group were significantly higher 6\u00a0h after <jats:styled-content style=\"fixed-case\">TAK<\/jats:styled-content>\u2010683 treatment than those in the control group (12.0\u00a0\u00b1\u00a010.7 vs 1.0\u00a0\u00b1\u00a00.7\u00a0ng\/ml for <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content>, 47.5\u00a0\u00b1\u00a028.2 vs 15.1\u00a0\u00b1\u00a03.4\u00a0ng\/ml for <jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content>, p\u00a0&lt;\u00a00.05), whereas mean concentrations of oestradiol in the treatment group decreased immediately after treatment (p\u00a0&lt;\u00a00.05) as compared with the control group. Ovulation tended to be delayed (n\u00a0=\u00a02) or occurred early (n\u00a0=\u00a01) in the treatment group as compared with the control group. For the second ovulation, ovulatory follicles in the treatment group were significantly smaller in maximal diameter than in the control group (3.8\u00a0\u00b1\u00a00.5 vs 5.4\u00a0\u00b1\u00a00.2\u00a0mm, p\u00a0&lt;\u00a00.05, n\u00a0=\u00a03). Administration of <jats:styled-content style=\"fixed-case\">TAK<\/jats:styled-content>\u2010683 in the follicular phase stimulates gonadotropin secretion and may have resulted in ovulation of premature follicles in goats.<\/jats:p>","DOI":"10.1111\/rda.12283","type":"journal-article","created":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T07:56:53Z","timestamp":1391241413000},"page":"338-342","source":"Crossref","is-referenced-by-count":24,"title":["Ovarian and Hormonal Responses to Follicular Phase Administration of Investigational Metastin\/Kisspeptin Analog, <scp>TAK<\/scp>\u2010683, in Goats"],"prefix":"10.1111","volume":"49","author":[{"given":"Y","family":"Goto","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Reproduction Tokyo University of Agriculture and Technology Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Endo","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Reproduction Tokyo University of Agriculture and Technology Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Nagai","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Reproduction Tokyo University of Agriculture and Technology Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Ohkura","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Production Science Graduate School of Bioagricultural Sciences Nagoya University Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Wakabayashi","sequence":"additional","affiliation":[{"name":"Laboratory of Neurobiology National Institute of Agrobiological Sciences Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Takeda Pharmaceutical Company, Ltd. Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Matsui","sequence":"additional","affiliation":[{"name":"Takeda Pharmaceutical Company, Ltd. Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Kusaka","sequence":"additional","affiliation":[{"name":"Takeda Pharmaceutical Company, Ltd. 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