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Nevertheless, postponement of puberty, that is, prevention of an increase in sexual hormones and thereby prevention of their manifold effects, is of major importance, not only in controlling overpopulation but also to preserve the genetic base for future breeding stock and pets. Therefore, alternatives for surgical suppression of fertility in pre\u2010pubertal animals were critically reviewed. As a promising alternative, the slow\u2010release<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>n<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>agonist deslorelin and other<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>n<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>analogues have been investigated. In female dogs and cats, puberty could be significantly postponed without initial flare\u2010up effect and without disturbance of body development. First trials to delay puberty in female and male cats by application of a 4.7\u2010mg deslorelin implant 24\u00a0h after birth so far are promising. In female dogs, a previous investigation showed that when the implant was inserted at the age of 4\u00a0months, the initial flare\u2010up effect was prevented. Body development was normal in the studies reviewed here, and with the 9.4\u2010mg implant, puberty was significantly delayed until the age of 21\u00a0months or older. In one study, bitches either received a 4.7\u2010 or a 9.4\u2010mg implant at the age of 4\u00a0months and the epiphyses were mostly closed before the time of first oestrus. Using a 4.7\u2010mg deslorelin implant in pre\u2010pubertal male dogs significantly postponed puberty, and age at puberty was &gt;2\u00a0years when a 9.4\u2010mg implant was used. However, further investigations are required, especially concerning the effect of different<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>n<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>agonist dosages and resorption rates on the duration of postponement of puberty as well as long\u2010term effects in both dogs and cats.<\/jats:p>","DOI":"10.1111\/rda.12330","type":"journal-article","created":{"date-parts":[[2014,6,20]],"date-time":"2014-06-20T12:45:35Z","timestamp":1403268335000},"page":"21-27","source":"Crossref","is-referenced-by-count":16,"title":["Suppression of Fertility in Pre\u2010pubertal Dogs and Cats"],"prefix":"10.1111","volume":"49","author":[{"given":"S","family":"Sch\u00e4fer\u2010Somi","sequence":"first","affiliation":[{"name":"Centre for Artificial Insemination and Embryo Transfer Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Kaya","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Veterinary Medicine University of Kafkas Kars Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"G\u00fcltiken","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Faculty of Veterinary Medicine University of Ondokuz Mayis Samsun Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Aslan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Faculty of Veterinary Medicine University of Ankara Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2012.03.030"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-97-3-693"},{"key":"e_1_2_10_4_1","first-page":"259","article-title":"Incontinentia urinae bei der kastrierten H\u00fcndin: H\u00e4ufigkeit und Rassedisposition","volume":"131","author":"Arnold S","year":"1989","journal-title":"Schweiz Arch Tierheilkd"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2011.01220.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2011.01176.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2009.11.004"},{"key":"e_1_2_10_8_1","unstructured":"CarranzaA BlancoP GarciaP de la SotaP GobelloC 2013:Effect of a GnRH agonist in immature domestic cats. 5th International Symposium on Non\u2010Surgical Contraceptive Methods of Pet Population Control. 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