{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T05:03:32Z","timestamp":1784005412059,"version":"3.55.0"},"reference-count":9,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,8,16]],"date-time":"2014-08-16T00:00:00Z","timestamp":1408147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Contents<\/jats:title><jats:p>This study aimed at evaluating the effects of angiotensin\u2010converting enzyme inhibitor (enalapril) and angiotensin <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> antagonist (valsartan) on the oestradiol and progesterone production in ewes submitted to oestrous synchronization protocol. The animals were weighed and randomly divided into three groups (n\u00a0=\u00a07). A pre\u2010experiment conducted to verify the effectiveness and toxicity of enalapril (0.5\u00a0mg\/kg <jats:styled-content style=\"fixed-case\">LW<\/jats:styled-content>) and valsartan (2.2\u00a0mg\/kg <jats:styled-content style=\"fixed-case\">LW<\/jats:styled-content>) showed that, in the doses used, these drugs were effective in reducing blood pressure without producing toxic effects. In the experiment, all animals were subjected to oestrous synchronization protocol during 12\u00a0days. On D10, D11 and D12, animals received saline, enalapril or valsartan (same doses of the pre\u2010experiment), according to the group randomly divided. The hormonal analysis showed an increase in oestradiol on the last day of the protocol (D12) in animals that received enalapril (p\u00a0&lt;\u00a00.05), but not in other groups, without changing the concentration of progesterone in any of the treatments. It is concluded that valsartan and enalapril are safe and effective subcutaneously for use in sheep and that the angiotensin\u2010converting enzyme (<jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content>) inhibition with enalapril leads to an increase in oestradiol production near ovulation without changing the concentration of progesterone. This shows that <jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content> inhibition may be a useful tool in reproductive biotechnologies involving induction and synchronization of oestrus and ovulation in sheep.<\/jats:p>","DOI":"10.1111\/rda.12384","type":"journal-article","created":{"date-parts":[[2014,8,16]],"date-time":"2014-08-16T07:55:13Z","timestamp":1408175713000},"source":"Crossref","is-referenced-by-count":6,"title":["Inhibition of Angiotensin\u2010Converting Enzyme Increases Oestradiol Production in Ewes Submitted to Oestrous Synchronization Protocol"],"prefix":"10.1111","volume":"49","author":[{"given":"AS","family":"Costa","sequence":"first","affiliation":[{"name":"Postgraduate in Animal Science Federal University of Piau\u00ed Teresina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AS","family":"Junior","sequence":"additional","affiliation":[{"name":"Postgraduate in Animal Science Federal University of Piau\u00ed Teresina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GEN","family":"Viana","sequence":"additional","affiliation":[{"name":"Department Morphophysiology Center Agricultural Sciences Federal University of Piau\u00ed Teresina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MCS","family":"Muratori","sequence":"additional","affiliation":[{"name":"Department Morphophysiology Center Agricultural Sciences Federal University of Piau\u00ed Teresina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AM","family":"Reis","sequence":"additional","affiliation":[{"name":"Departament de Physiology Institute of Biological Sciences Federal University of Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"APR","family":"Costa","sequence":"additional","affiliation":[{"name":"Department Morphophysiology Center Agricultural Sciences Federal University of Piau\u00ed Teresina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2004000800017"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2002-220787"},{"key":"e_1_2_8_4_1","first-page":"716","volume-title":"Goodman and Gilman as bases farmacol\u00f3gicas da terap\u00eautica","author":"Jackson EK","year":"2010"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2005-0245"},{"key":"e_1_2_8_6_1","first-page":"25","volume-title":"Biot\u00e9cnicas Aplicadas \u00e0 Reprodu\u00e7\u00e3o Animal","author":"Moraes JCF","year":"2002"},{"key":"e_1_2_8_7_1","first-page":"124","volume-title":"Caprinocultura: Cria\u00e7\u00e3o Racional De Caprinos","author":"Ribeiro SDA","year":"1998"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2010.01.019"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000251865.35728.2f"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2011.058453"}],"container-title":["Reproduction in Domestic Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Frda.12384","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/rda.12384","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T13:57:42Z","timestamp":1696168662000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/rda.12384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,16]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1111\/rda.12384"],"URL":"https:\/\/doi.org\/10.1111\/rda.12384","archive":["Portico"],"relation":{},"ISSN":["0936-6768","1439-0531"],"issn-type":[{"value":"0936-6768","type":"print"},{"value":"1439-0531","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,16]]}}}